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- W1965895778 abstract "A novel hydrazone, 4-chloro-N′-(pyridin-2-ylmethylene)benzohydrazide (CPBH) has been synthesized through a one-pot synthesis method and used as a chemical probe to find the structural cause of the unusual static quenching mechanism in the interaction with serum albumin. The adsorption of CPBH by bovine/human serum albumin (BSA/HSA) has been investigated systematically by comprehensive spectroscopy, modeling, electrochemistry and microcalorimetry under physiological conditions. CPBH forms a complex with BSA/HSA with the binding site in Sudlow's site I of BSA/HSA. The adverse temperature dependence in the unusual static quenching is found to be a reasonable consequence of the large activation energy requirement in the binding process, which is required to overcome the structural block and it is a direct result of the unique microstructure of the binding pocket." @default.
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- W1965895778 date "2012-01-01" @default.
- W1965895778 modified "2023-10-18" @default.
- W1965895778 title "The adsorption of an anticancer hydrazone by protein: an unusual static quenching mechanism" @default.
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- W1965895778 doi "https://doi.org/10.1039/c1ra00521a" @default.
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