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- W1965909762 abstract "The effect of progesterone on oxytocin-stimulated intracellular Ca 2+ mobilisation and prostaglandin secretion in porcine endometrium We have studied in the porcine endometrium the expression of oxytocin receptor ( OTR ) mRNA and the effect of progesterone (P 4 ) on oxytocin/oxytocin receptor (OT/OTR) function concerning intracellular Ca 2+ mobilisation ([Ca 2+ ] i ), prostaglandin F2α (PGF2α) and E2 (PGE2; PG) secretion. Tissue was taken from cyclic and early pregnant pigs (days 14-16). A higher expression of OTR mRNA (P<0.05) was observed in the endometrium of cyclic than pregnant pigs. The stimulatory (P<0.05) effect of OT (10 -7 M) on [Ca 2+ ] i mobilisation was noticed within 15-60 s and 30-60 s in endometrial stromal cells of cyclic and pregnant pigs, respectively. In the presence of P 4 (10 -5 M) basal and OT-stimulated [Ca 2+ ] i concentrations decreased in stromal cells during luteolysis and pregnancy. In stromal cells P 4 delayed mobilisation of [Ca 2+ ] i in response to OT by 15 s during luteolysis and had no effect during pregnancy. In cyclic and pregnant epithelial cells OT stimulated mobilisation of [Ca 2+ ] i in 45 s and 60 s, respectively. Oxytocin increased (P<0.05) PGF2α secretion during luteolysis and pregnancy and PGE2 during luteolysis from endometrial slices. Progesterone did not inhibit this stimulatory effect. During luteolysis OT increased (P<0.05) PGF2α in epithelial and stromal cells and PGE2 secretion in epithelial cells. In the presence of P 4 this effect of OT was reduced only in stromal cyclic cells (6 h culture). The presence of P 4 decreased the effect of OT on [Ca 2+ ] i mobilisation only in stromal cells. We found that, in most conditions, P 4 did not inhibit the OT-stimulated secretion of PG in the porcine endometrium." @default.
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- W1965909762 date "2010-12-01" @default.
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- W1965909762 title "The effect of progesterone on oxytocin-stimulated intracellular Ca2+ mobilisation and prostaglandin secretion in porcine endometrium" @default.
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- W1965909762 doi "https://doi.org/10.2478/v10181-010-0012-5" @default.
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