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- W1965918097 abstract "Background: Implantable cardioverter-defibrillator (ICD) should be a primary therapy for prevention of sudden cardiac death. Although amiodarone therapy (AMD) would also be applied, the benefit of combination of ICD and AMD is unclear. In this study, we retrospectively evaluated the incidence of VT/VF recurrence in ICD patients with and without AMD. Methods: The study population consisted of 75 patients with ICD therapy with structural heart diseases. They were divided into two groups with and without AMD and the incidence of VT/VF recurrence was compared between the 2 groups. Results: AMD was applied in 22/75 patients (29%). During the follow-up period of 23±3 months, VT/VF recurred in 7/22 in patients with AMD (32%) and 31/53 without AMD (58%, p=0.035). In sub-group analysis with and without left ventricular (LV) dysfunction (LV ejection fraction: LVEF<40%), VT/VF recurrence rate was lower in AMD group in patients with LVEF<40% (p=0.024), but no difference was observed in patients with LVEF>40%. In the Kaplan-Meyer analysis, VT/VF recurrence rate was not different in 0-12 month observation, but the difference became significant later than 36 months (p=0.044). Conclusions: Although AMD tended to be applied for patients with higher risk in the retrospective observation, AMD was considered to decrease VT/VF recurrence in ICD patients especially in population with structural heart disease and lower LVEF." @default.
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- W1965918097 date "2009-09-01" @default.
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- W1965918097 title "The Long Term Effect of Amiodarone Therapy for Prevention of Arrhythmic Events in Patients With Implantable Cardioverter-Defibrillator (ICD)" @default.
- W1965918097 doi "https://doi.org/10.1016/j.cardfail.2009.07.127" @default.
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