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- W1965920432 abstract "Schizophrenia (SZ) is a common and severe psychiatric disorder with both environmental and genetic risk factors, and a high heritability. After over 20 years of molecular genetics research, new molecular strategies, primarily genome-wide association studies (GWAS), have generated major tangible progress. This new data provides evidence for: (1) a number of chromosomal regions with common polymorphisms showing genome-wide association with SZ (the major histocompatibility complex, MHC, region at 6p22–p21; 18q21.2; and 2q32.1). The associated alleles present small odds ratios (the odds of a risk variant being present in cases vs. controls) and suggest causative involvement of gene regulatory mechanisms in SZ. (2) Polygenic inheritance. (3) Involvement of rare (<1%) and large (>100 kb) copy number variants (CNVs). (4) A genetic overlap of SZ with autism and with bipolar disorder (BP) challenging the classical clinical classifications. Most new SZ findings (chromosomal regions and genes) have generated new biological leads. These new findings, however, still need to be translated into a better understanding of the underlying biology and into causal mechanisms. Furthermore, a considerable amount of heritability still remains unexplained (missing heritability). Deep resequencing for rare variants and system biology approaches (e.g., integrating DNA sequence and functional data) are expected to further improve our understanding of the genetic architecture of SZ and its underlying biology." @default.
- W1965920432 created "2016-06-24" @default.
- W1965920432 creator A5014402793 @default.
- W1965920432 creator A5020329452 @default.
- W1965920432 creator A5072607022 @default.
- W1965920432 date "2010-09-01" @default.
- W1965920432 modified "2023-10-18" @default.
- W1965920432 title "Genome-wide approaches to schizophrenia" @default.
- W1965920432 cites W1733355263 @default.
- W1965920432 cites W1831476346 @default.
- W1965920432 cites W1966736403 @default.
- W1965920432 cites W1967318257 @default.
- W1965920432 cites W1971191942 @default.
- W1965920432 cites W1971321176 @default.
- W1965920432 cites W1971624220 @default.
- W1965920432 cites W1973502710 @default.
- W1965920432 cites W1976414637 @default.
- W1965920432 cites W1978215768 @default.
- W1965920432 cites W1980991473 @default.
- W1965920432 cites W1981509058 @default.
- W1965920432 cites W1983837040 @default.
- W1965920432 cites W1985034219 @default.
- W1965920432 cites W1988036288 @default.
- W1965920432 cites W1990436516 @default.
- W1965920432 cites W1991145039 @default.
- W1965920432 cites W1991500494 @default.
- W1965920432 cites W1993020997 @default.
- W1965920432 cites W1996124672 @default.
- W1965920432 cites W1997031801 @default.
- W1965920432 cites W1997489121 @default.
- W1965920432 cites W1998957301 @default.
- W1965920432 cites W1998979210 @default.
- W1965920432 cites W2002960068 @default.
- W1965920432 cites W2005848760 @default.
- W1965920432 cites W2006085234 @default.
- W1965920432 cites W2006395252 @default.
- W1965920432 cites W2008599922 @default.
- W1965920432 cites W2011920499 @default.
- W1965920432 cites W2014596655 @default.
- W1965920432 cites W2014787267 @default.
- W1965920432 cites W2019465651 @default.
- W1965920432 cites W2019983262 @default.
- W1965920432 cites W2023098599 @default.
- W1965920432 cites W2023171821 @default.
- W1965920432 cites W2024910541 @default.
- W1965920432 cites W2025142408 @default.
- W1965920432 cites W2025156429 @default.
- W1965920432 cites W2027455260 @default.
- W1965920432 cites W2027504487 @default.
- W1965920432 cites W2028871486 @default.
- W1965920432 cites W2031999522 @default.
- W1965920432 cites W2035074730 @default.
- W1965920432 cites W2035380874 @default.
- W1965920432 cites W2035799305 @default.
- W1965920432 cites W2037247014 @default.
- W1965920432 cites W2040618467 @default.
- W1965920432 cites W2043355615 @default.
- W1965920432 cites W2047031939 @default.
- W1965920432 cites W2047200356 @default.
- W1965920432 cites W2047361940 @default.
- W1965920432 cites W2047565527 @default.
- W1965920432 cites W2049595315 @default.
- W1965920432 cites W2050161506 @default.
- W1965920432 cites W2053610456 @default.
- W1965920432 cites W2054334091 @default.
- W1965920432 cites W2058148991 @default.
- W1965920432 cites W2058498398 @default.
- W1965920432 cites W2059222949 @default.
- W1965920432 cites W2059867286 @default.
- W1965920432 cites W2060392690 @default.
- W1965920432 cites W2063381162 @default.
- W1965920432 cites W2063994095 @default.
- W1965920432 cites W2065776802 @default.
- W1965920432 cites W2069378182 @default.
- W1965920432 cites W2075183590 @default.
- W1965920432 cites W2075199575 @default.
- W1965920432 cites W2076793571 @default.
- W1965920432 cites W2077016335 @default.
- W1965920432 cites W2077560413 @default.
- W1965920432 cites W2079098929 @default.
- W1965920432 cites W2079517684 @default.
- W1965920432 cites W2080183225 @default.
- W1965920432 cites W2082462537 @default.
- W1965920432 cites W2082647438 @default.
- W1965920432 cites W2083381199 @default.
- W1965920432 cites W2084955584 @default.
- W1965920432 cites W2087261765 @default.
- W1965920432 cites W2087276835 @default.
- W1965920432 cites W2087685535 @default.
- W1965920432 cites W2088466641 @default.
- W1965920432 cites W2089843122 @default.
- W1965920432 cites W2090183355 @default.
- W1965920432 cites W2091467970 @default.
- W1965920432 cites W2093707428 @default.
- W1965920432 cites W2095119525 @default.
- W1965920432 cites W2095232450 @default.
- W1965920432 cites W2095597256 @default.
- W1965920432 cites W2097117811 @default.