Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965932017> ?p ?o ?g. }
- W1965932017 endingPage "1482" @default.
- W1965932017 startingPage "1477" @default.
- W1965932017 abstract "Several 1,4-bis(indolin-1-ylmethyl)benzene-based compounds containing substituents such as five, six and seven cyclic derivatives on indeno part (9a-c) were prepared and tested against two members of the pH regulatory enzyme family, carbonic anhydrase (CA). The inhibitory potencies of the compounds at the human isoforms hCA I and hCA II targets were analyzed and KI values were calculated. KI values of compounds for hCA I and hCA II human isozymes were measured in the range of 39.3-42.6μM and 0.17-0.29μM, respectively. The structurally related compound indole was also tested in order to understand the structure-activity relationship. Most of the compounds showed good CA inhibitory efficacy. In silico docking studies of these derivatives within hCA I and II were also carried out and results are supported the kinetic assays." @default.
- W1965932017 created "2016-06-24" @default.
- W1965932017 creator A5021780004 @default.
- W1965932017 creator A5051175831 @default.
- W1965932017 creator A5055539632 @default.
- W1965932017 creator A5058634047 @default.
- W1965932017 creator A5080235407 @default.
- W1965932017 date "2013-03-01" @default.
- W1965932017 modified "2023-09-27" @default.
- W1965932017 title "Synthesis of 1,4-bis(indolin-1-ylmethyl)benzene derivatives and their structure–activity relationships for the interaction of human carbonic anhydrase isoforms I and II" @default.
- W1965932017 cites W1513087030 @default.
- W1965932017 cites W1814763565 @default.
- W1965932017 cites W1895941201 @default.
- W1965932017 cites W1964713930 @default.
- W1965932017 cites W1967412933 @default.
- W1965932017 cites W1969694148 @default.
- W1965932017 cites W1970221679 @default.
- W1965932017 cites W1972953685 @default.
- W1965932017 cites W1975376822 @default.
- W1965932017 cites W1975691556 @default.
- W1965932017 cites W1982889315 @default.
- W1965932017 cites W1984642014 @default.
- W1965932017 cites W1997211320 @default.
- W1965932017 cites W1999593239 @default.
- W1965932017 cites W2001795074 @default.
- W1965932017 cites W2006113231 @default.
- W1965932017 cites W2020880561 @default.
- W1965932017 cites W2021669959 @default.
- W1965932017 cites W2021856501 @default.
- W1965932017 cites W2025766128 @default.
- W1965932017 cites W2027173571 @default.
- W1965932017 cites W2029654893 @default.
- W1965932017 cites W2045506684 @default.
- W1965932017 cites W2046629801 @default.
- W1965932017 cites W2047178318 @default.
- W1965932017 cites W2050456292 @default.
- W1965932017 cites W2051349300 @default.
- W1965932017 cites W2052148191 @default.
- W1965932017 cites W2052876074 @default.
- W1965932017 cites W2054838817 @default.
- W1965932017 cites W2069959559 @default.
- W1965932017 cites W2074631079 @default.
- W1965932017 cites W2079574255 @default.
- W1965932017 cites W2081839616 @default.
- W1965932017 cites W2082663466 @default.
- W1965932017 cites W2084330715 @default.
- W1965932017 cites W2097051605 @default.
- W1965932017 cites W2100837269 @default.
- W1965932017 cites W2102377211 @default.
- W1965932017 cites W2125916691 @default.
- W1965932017 cites W2128627005 @default.
- W1965932017 cites W2131861685 @default.
- W1965932017 cites W2137047761 @default.
- W1965932017 cites W2146370713 @default.
- W1965932017 cites W2148144144 @default.
- W1965932017 cites W2151573674 @default.
- W1965932017 cites W2169128564 @default.
- W1965932017 cites W2179162529 @default.
- W1965932017 cites W2950356390 @default.
- W1965932017 cites W4293247451 @default.
- W1965932017 cites W2154936507 @default.
- W1965932017 doi "https://doi.org/10.1016/j.bmc.2012.09.027" @default.
- W1965932017 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23121721" @default.
- W1965932017 hasPublicationYear "2013" @default.
- W1965932017 type Work @default.
- W1965932017 sameAs 1965932017 @default.
- W1965932017 citedByCount "10" @default.
- W1965932017 countsByYear W19659320172013 @default.
- W1965932017 countsByYear W19659320172014 @default.
- W1965932017 countsByYear W19659320172015 @default.
- W1965932017 countsByYear W19659320172016 @default.
- W1965932017 countsByYear W19659320172018 @default.
- W1965932017 countsByYear W19659320172023 @default.
- W1965932017 crossrefType "journal-article" @default.
- W1965932017 hasAuthorship W1965932017A5021780004 @default.
- W1965932017 hasAuthorship W1965932017A5051175831 @default.
- W1965932017 hasAuthorship W1965932017A5055539632 @default.
- W1965932017 hasAuthorship W1965932017A5058634047 @default.
- W1965932017 hasAuthorship W1965932017A5080235407 @default.
- W1965932017 hasConcept C104317684 @default.
- W1965932017 hasConcept C114373084 @default.
- W1965932017 hasConcept C119795356 @default.
- W1965932017 hasConcept C159110408 @default.
- W1965932017 hasConcept C178790620 @default.
- W1965932017 hasConcept C181199279 @default.
- W1965932017 hasConcept C185592680 @default.
- W1965932017 hasConcept C192527728 @default.
- W1965932017 hasConcept C193042331 @default.
- W1965932017 hasConcept C202751555 @default.
- W1965932017 hasConcept C2775905019 @default.
- W1965932017 hasConcept C2775914622 @default.
- W1965932017 hasConcept C2777691172 @default.
- W1965932017 hasConcept C2780416268 @default.
- W1965932017 hasConcept C2911210155 @default.
- W1965932017 hasConcept C2992453875 @default.
- W1965932017 hasConcept C41685203 @default.
- W1965932017 hasConcept C53345823 @default.
- W1965932017 hasConcept C55493867 @default.