FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965957522> ?p ?o ?g. }

• W1965957522 endingPage "827" @default.
• W1965957522 startingPage "817" @default.
• W1965957522 abstract "The Keap1-Nrf2 system plays a critical role in cellular defense against electrophiles and reactive oxygen species. Keap1 possesses a number of cysteine residues, some of which are highly reactive and serves as sensors for these insults. Indeed, point mutation of Cys151 abrogates the response to certain electrophiles. However, this mutation does not affect the other set of electrophiles, suggesting that multiple sensor systems reside within the cysteine residues of Keap1. The precise contribution of each reactive cysteine to the sensor function of Keap1 remains to be clarified. To elucidate the contribution of Cys151 in vivo, in this study we adopted transgenic complementation rescue assays. Embryonic fibroblasts and primary peritoneal macrophages were prepared from mice expressing the Keap1-C151S mutant. These cells were challenged with various Nrf2 inducers. We found that some of the inducers triggered only marginal responses in Keap1-C151S-expressing cells, while others evoked responses in a comparable magnitude to those observed in the wild-type cells. We found that tert-butyl hydroquinone, diethylmaleate, sulforaphane, and dimethylfumarate were Cys151 preferable, whereas 15-deoxy-Δ(12,14)-prostaglandin J(2) (15d-PG-J(2)), 2-cyano-3,12 dioxooleana-1,9 diene-28-imidazolide (CDDO-Im), ebselen, nitro-oleic acid, and cadmium chloride were Cys151 independent. Experiments with embryonic fibroblasts and primary macrophages yielded consistent results. Experiments testing protective effects against the cytotoxicity of 1-chloro-2,4-dinitrobenzene of sulforaphane and 15d-PG-J(2) in Keap1-C151S-expressing macrophages revealed that the former inducer was effective, while the latter was not. These results thus indicate that there exists distinct utilization of Keap1 cysteine residues by different chemicals that trigger the response of the Keap1-Nrf2 system, and further substantiate the notion that there are multiple sensing mechanisms within Keap1 cysteine residues." @default.
• W1965957522 created "2016-06-24" @default.
• W1965957522 creator A5016514006 @default.
• W1965957522 creator A5058903427 @default.
• W1965957522 creator A5060218795 @default.
• W1965957522 creator A5066933880 @default.
• W1965957522 creator A5067454062 @default.
• W1965957522 creator A5072089972 @default.
• W1965957522 creator A5078166804 @default.
• W1965957522 date "2012-08-01" @default.
• W1965957522 modified "2023-10-05" @default.
• W1965957522 title "Validation of the multiple sensor mechanism of the Keap1-Nrf2 system" @default.
• W1965957522 cites W1631169176 @default.
• W1965957522 cites W1643210644 @default.
• W1965957522 cites W1964716294 @default.
• W1965957522 cites W1966781309 @default.
• W1965957522 cites W1966830269 @default.
• W1965957522 cites W1968883331 @default.
• W1965957522 cites W1972010933 @default.
• W1965957522 cites W1974755487 @default.
• W1965957522 cites W1978094617 @default.
• W1965957522 cites W1982380290 @default.
• W1965957522 cites W1983743651 @default.
• W1965957522 cites W1986377088 @default.
• W1965957522 cites W1987056806 @default.
• W1965957522 cites W1987857240 @default.
• W1965957522 cites W1996095483 @default.
• W1965957522 cites W2000198750 @default.
• W1965957522 cites W2021270662 @default.
• W1965957522 cites W2038528121 @default.
• W1965957522 cites W2040499888 @default.
• W1965957522 cites W2041154760 @default.
• W1965957522 cites W2050599166 @default.
• W1965957522 cites W2054780866 @default.
• W1965957522 cites W2064178836 @default.
• W1965957522 cites W2069159655 @default.
• W1965957522 cites W2076935230 @default.
• W1965957522 cites W2083882252 @default.
• W1965957522 cites W2089097264 @default.
• W1965957522 cites W2094661084 @default.
• W1965957522 cites W2096822241 @default.
• W1965957522 cites W2097634036 @default.
• W1965957522 cites W2103684100 @default.
• W1965957522 cites W2114101650 @default.
• W1965957522 cites W2122116064 @default.
• W1965957522 cites W2124417387 @default.
• W1965957522 cites W2125297232 @default.
• W1965957522 cites W2125762200 @default.
• W1965957522 cites W2126635195 @default.
• W1965957522 cites W2130029858 @default.
• W1965957522 cites W2134172788 @default.
• W1965957522 cites W2135277493 @default.
• W1965957522 cites W2137894554 @default.
• W1965957522 cites W2150304189 @default.
• W1965957522 cites W2155324869 @default.
• W1965957522 cites W2161982997 @default.
• W1965957522 cites W2164672742 @default.
• W1965957522 cites W2168395641 @default.
• W1965957522 doi "https://doi.org/10.1016/j.freeradbiomed.2012.06.023" @default.
• W1965957522 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3539416" @default.
• W1965957522 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22732183" @default.
• W1965957522 hasPublicationYear "2012" @default.
• W1965957522 type Work @default.
• W1965957522 sameAs 1965957522 @default.
• W1965957522 citedByCount "221" @default.
• W1965957522 countsByYear W19659575222012 @default.
• W1965957522 countsByYear W19659575222013 @default.
• W1965957522 countsByYear W19659575222014 @default.
• W1965957522 countsByYear W19659575222015 @default.
• W1965957522 countsByYear W19659575222016 @default.
• W1965957522 countsByYear W19659575222017 @default.
• W1965957522 countsByYear W19659575222018 @default.
• W1965957522 countsByYear W19659575222019 @default.
• W1965957522 countsByYear W19659575222020 @default.
• W1965957522 countsByYear W19659575222021 @default.
• W1965957522 countsByYear W19659575222022 @default.
• W1965957522 countsByYear W19659575222023 @default.
• W1965957522 crossrefType "journal-article" @default.
• W1965957522 hasAuthorship W1965957522A5016514006 @default.
• W1965957522 hasAuthorship W1965957522A5058903427 @default.
• W1965957522 hasAuthorship W1965957522A5060218795 @default.
• W1965957522 hasAuthorship W1965957522A5066933880 @default.
• W1965957522 hasAuthorship W1965957522A5067454062 @default.
• W1965957522 hasAuthorship W1965957522A5072089972 @default.
• W1965957522 hasAuthorship W1965957522A5078166804 @default.
• W1965957522 hasBestOaLocation W19659575222 @default.
• W1965957522 hasConcept C104317684 @default.
• W1965957522 hasConcept C143065580 @default.
• W1965957522 hasConcept C181199279 @default.
• W1965957522 hasConcept C185592680 @default.
• W1965957522 hasConcept C188082640 @default.
• W1965957522 hasConcept C2776529522 @default.
• W1965957522 hasConcept C2779201268 @default.
• W1965957522 hasConcept C2780841255 @default.
• W1965957522 hasConcept C55493867 @default.
• W1965957522 hasConcept C86339819 @default.
• W1965957522 hasConcept C86803240 @default.
• W1965957522 hasConcept C95444343 @default.

• next