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- W1965979066 abstract "Abstract We report on a novel strategy for identification of specific sulfation motifs in chondroitin/dermatan sulfate (CS/DS) chain derived from decorin (Dcn), based on enzyme cleavage and multistage MS (MS n ). Released CS/DS chains were digested with chondroitin B and in parallel with AC I lyases to obtain oligosaccharides of known hexuronic acid (HexA) epimerization. The depolymerized chains were separated by gel filtration, and collected di‐ and hexasaccharides were analyzed by ESI MS n . MS 2 on bisulfated 4,5‐Δ‐HexAGalNAc revealed an additional sulfate ester group at 4,5‐Δ‐HexA. MS 2 data provided evidence upon GlcA sulfation in Dcn due to the fact that 4,5‐Δ‐HexA derived from GlcA after chondroitin AC I lyase treatment. Hexasaccharide screening in the MS 1 mode indicated direct correlation between the sulfate distribution and HexA epimerization. MS n performed on ions that, according to mass calculation, correspond to pentasulfated [4,5‐Δ‐HexAGalNAc(GlcAGalNAc) 2 ], trisulfated [4,5‐Δ‐HexAGalNAc(GlcAGalNAc) 2 ] with IdoA‐derived 4,5‐Δ‐HexA at the nonreducing end, tetrasulfated [4,5‐Δ‐HexAGalNAc(IdoAGalNAc) 2 ] and monosulfated [4,5‐Δ‐HexAGalNAc(IdoAGalNAc) 2 ] with GlcA‐derived 4,5‐Δ‐HexA at the nonreducing end rendered fragmentation patterns confirming the presence of over‐, regular, and under‐sulfated regions as well as structural motifs having both types of HexA sulfated within Dcn CS/DS." @default.
- W1965979066 created "2016-06-24" @default.
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- W1965979066 date "2009-07-01" @default.
- W1965979066 modified "2023-10-17" @default.
- W1965979066 title "Analysis of novel over- and under-sulfated glycosaminoglycan sequences by enzyme cleavage and multiple stage MS" @default.
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- W1965979066 doi "https://doi.org/10.1002/pmic.200800440" @default.
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