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• W1965984080 abstract "Objective: To investigate the contribution of the estrogen receptor α (ERα) polymorphism in the development of obstetric cholestasis and to determine whether multidrug resistance 3 (MDR3) gene 1712delT mutation detected in French patients is also present in Finnish women with obstetric cholestasis. Study design: In a retrospective case-control study, two ERα polymorphisms and MDR3 gene mutation 1712delT were investigated in healthy control women (N=47) and in women with diagnosis of obsteric cholestasis (N=57). PvuII and XbaI polymorphisms in ERα gene were evaluated in genomic DNA by using the polymerase chain reaction (PCR). In addition, the frequencies in the general population in our area are presented for comparison. Results: None of the ERα genotypes or alleles was significantly over-represented in obstetric cholestasis. When the two ERα gene polymorphisms were analyzed in parallel, six genotype combinations were recognized, and the distribution of these genotype combinations did not reveal statistically significant differences between the cases and controls (P=0.612). No patient or control was heterozygous or homozygous for the mutant allele in the MDR3 gene. Conclusion: The present data indicate that polymorphism of the ERα gene and MDR3 gene 1712delT mutation are unlikely to play any significant role in obstetric cholestasis in affected Finnish women. Further work to identify explanatory factors is of particular interest." @default.
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• W1965984080 date "2002-09-01" @default.
• W1965984080 modified "2023-10-16" @default.
• W1965984080 title "Multidrug resistance 3 gene mutation 1712delT and estrogen receptor α gene polymorphisms in Finnish women with obstetric cholestasis" @default.
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• W1965984080 doi "https://doi.org/10.1016/s0301-2115(02)00064-7" @default.
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