Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965991076> ?p ?o ?g. }
Showing items 1 to 82 of
82
with 100 items per page.
- W1965991076 endingPage "447" @default.
- W1965991076 startingPage "441" @default.
- W1965991076 abstract "Glutathione S-transferases are involved in the conjugation of a number of human carcinogens. The frequencies of the deletion alleles coding for GSTM1, and GSTT1, related to deficient conjugation of xenobiotics, as well as a recently reported variant in the exon 5 of GSTP1 were investigated in this study. A multiplex polymerase chain reaction based method for a rapid and high throughput genotype analysis of all three GSTM1, GSTT1 and GSTP1 genes in a single tube was developed. Leukocyte DNA from two hundred and thirty-nine (n=239) breast cancer patients were genotyped. Tumors from a subset of these breast cancer patients (n=131) have previously been investigated for mutations in the TP53 gene, levels of p53 protein accumulation and loss of heterozygosity at several loci on chromosome 17. When genetic alterations in the tumors were analyzed with respect to glutathione S-transferase genotypes, a significantly higher proportion of the patients with a G allele (GG + AG) of the GSTP1 had loss of heterozygosity at the TP53 gene locus mapping to 17p, compared with non-G allele carriers (74% versus 29%) (P=0.018). The patients carrying the G allele of GSTP1 also had more frequently mutations in the TP53 gene in their tumor (38%), compared with patients with the AA genotype (21%) (P=0.055). G allele carriers had predominantly deletion or transversion mutations in the TP53 gene (5 of 7 and 5 of 6 respectively). A higher frequency of the G allele carriers was observed among patiets with negative lymph node status (P=0.0004). A higher proportion of the patients with positive lymph node status at the time of diagnosis had a combined GSTM1 null/GSTTl null genotype (P=0.05). Patients who were homozygous for the deleted GSTM1 allele were found to have a Significantly s h o r t e r Overall Survival (P=0.036 )" @default.
- W1965991076 created "2016-06-24" @default.
- W1965991076 creator A5001621913 @default.
- W1965991076 creator A5006203531 @default.
- W1965991076 creator A5032124391 @default.
- W1965991076 creator A5032336324 @default.
- W1965991076 creator A5039174090 @default.
- W1965991076 creator A5059334301 @default.
- W1965991076 creator A5079804481 @default.
- W1965991076 date "1998-10-01" @default.
- W1965991076 modified "2023-10-17" @default.
- W1965991076 title "Single tube multiplex polymerase chain reaction genotype analysis of GSTM1, GSTT1 and GSTP1: relation of genotypes to TP53 tumor status and clinicopathological variables in breast cancer patients" @default.
- W1965991076 doi "https://doi.org/10.1097/00008571-199810000-00009" @default.
- W1965991076 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9825836" @default.
- W1965991076 hasPublicationYear "1998" @default.
- W1965991076 type Work @default.
- W1965991076 sameAs 1965991076 @default.
- W1965991076 citedByCount "86" @default.
- W1965991076 countsByYear W19659910762012 @default.
- W1965991076 countsByYear W19659910762014 @default.
- W1965991076 countsByYear W19659910762015 @default.
- W1965991076 countsByYear W19659910762017 @default.
- W1965991076 crossrefType "journal-article" @default.
- W1965991076 hasAuthorship W1965991076A5001621913 @default.
- W1965991076 hasAuthorship W1965991076A5006203531 @default.
- W1965991076 hasAuthorship W1965991076A5032124391 @default.
- W1965991076 hasAuthorship W1965991076A5032336324 @default.
- W1965991076 hasAuthorship W1965991076A5039174090 @default.
- W1965991076 hasAuthorship W1965991076A5059334301 @default.
- W1965991076 hasAuthorship W1965991076A5079804481 @default.
- W1965991076 hasConcept C104317684 @default.
- W1965991076 hasConcept C121608353 @default.
- W1965991076 hasConcept C135763542 @default.
- W1965991076 hasConcept C143589142 @default.
- W1965991076 hasConcept C153911025 @default.
- W1965991076 hasConcept C180754005 @default.
- W1965991076 hasConcept C2780122483 @default.
- W1965991076 hasConcept C49105822 @default.
- W1965991076 hasConcept C502942594 @default.
- W1965991076 hasConcept C530470458 @default.
- W1965991076 hasConcept C54355233 @default.
- W1965991076 hasConcept C555283112 @default.
- W1965991076 hasConcept C84597430 @default.
- W1965991076 hasConcept C86803240 @default.
- W1965991076 hasConcept C90583042 @default.
- W1965991076 hasConceptScore W1965991076C104317684 @default.
- W1965991076 hasConceptScore W1965991076C121608353 @default.
- W1965991076 hasConceptScore W1965991076C135763542 @default.
- W1965991076 hasConceptScore W1965991076C143589142 @default.
- W1965991076 hasConceptScore W1965991076C153911025 @default.
- W1965991076 hasConceptScore W1965991076C180754005 @default.
- W1965991076 hasConceptScore W1965991076C2780122483 @default.
- W1965991076 hasConceptScore W1965991076C49105822 @default.
- W1965991076 hasConceptScore W1965991076C502942594 @default.
- W1965991076 hasConceptScore W1965991076C530470458 @default.
- W1965991076 hasConceptScore W1965991076C54355233 @default.
- W1965991076 hasConceptScore W1965991076C555283112 @default.
- W1965991076 hasConceptScore W1965991076C84597430 @default.
- W1965991076 hasConceptScore W1965991076C86803240 @default.
- W1965991076 hasConceptScore W1965991076C90583042 @default.
- W1965991076 hasIssue "5" @default.
- W1965991076 hasLocation W19659910761 @default.
- W1965991076 hasLocation W19659910762 @default.
- W1965991076 hasOpenAccess W1965991076 @default.
- W1965991076 hasPrimaryLocation W19659910761 @default.
- W1965991076 hasRelatedWork W118167744 @default.
- W1965991076 hasRelatedWork W1965726430 @default.
- W1965991076 hasRelatedWork W1983574409 @default.
- W1965991076 hasRelatedWork W1995257130 @default.
- W1965991076 hasRelatedWork W2027506631 @default.
- W1965991076 hasRelatedWork W2131839889 @default.
- W1965991076 hasRelatedWork W2157891295 @default.
- W1965991076 hasRelatedWork W2163650164 @default.
- W1965991076 hasRelatedWork W2384927114 @default.
- W1965991076 hasRelatedWork W2414907829 @default.
- W1965991076 hasVolume "8" @default.
- W1965991076 isParatext "false" @default.
- W1965991076 isRetracted "false" @default.
- W1965991076 magId "1965991076" @default.
- W1965991076 workType "article" @default.