FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1965995589> ?p ?o ?g. }

• W1965995589 endingPage "3152" @default.
• W1965995589 startingPage "3140" @default.
• W1965995589 abstract "In the present study, effects of alterations in the chemical structure of polyester-co-polyether (PEPE) dendrimers on the encapsulation and release of methotrexate (MTX) was investigated. A series of PEPE dendrimers of different architecture were synthesized. Biocompatibility of the resulting dendrimers was evaluated in vitro by assessing their cytotoxicity on RAW 264.7 cells using lactate dehydrogenase (LDH) assay. Dendrimers caused no cell death even at the concentration of 250 μg/mL, suggesting that they are acceptable for pharmaceutical applications. They also showed good capacity to encapsulate MTX, with loading as high as 24.5% w/w. Increase in the number of branches and the size of internal voids were shown to enhance the encapsulation. On the other hand, absence of aromatic rings as branching units drastically reduced the loading capacity. Physical entrapment, weak hydrogen bonding and hydrophobic interactions were established to be the mechanisms of encapsulation. Release of MTX was biphasic, which included a burst release in 6 h followed by a slower release over a period of 50 or 168 h. Increase in the number of branches profoundly decreased this initial burst release; in contrast, absence of aromatic rings in the dendritic structure resulted in a very rapid release." @default.
• W1965995589 created "2016-06-24" @default.
• W1965995589 creator A5021090087 @default.
• W1965995589 creator A5086881309 @default.
• W1965995589 date "2007-07-01" @default.
• W1965995589 modified "2023-10-17" @default.
• W1965995589 title "Influence of molecular architecture of polyether-co-polyester dendrimers on the encapsulation and release of methotrexate" @default.
• W1965995589 cites W100843351 @default.
• W1965995589 cites W1572819095 @default.
• W1965995589 cites W1625348810 @default.
• W1965995589 cites W1964245862 @default.
• W1965995589 cites W1967476217 @default.
• W1965995589 cites W1968324199 @default.
• W1965995589 cites W1969978151 @default.
• W1965995589 cites W1972730594 @default.
• W1965995589 cites W1978263068 @default.
• W1965995589 cites W1995305826 @default.
• W1965995589 cites W1999161268 @default.
• W1965995589 cites W2001018320 @default.
• W1965995589 cites W2004933213 @default.
• W1965995589 cites W2013875806 @default.
• W1965995589 cites W2017847010 @default.
• W1965995589 cites W2018470991 @default.
• W1965995589 cites W2022549879 @default.
• W1965995589 cites W2023851343 @default.
• W1965995589 cites W2024745369 @default.
• W1965995589 cites W2044670947 @default.
• W1965995589 cites W2064605066 @default.
• W1965995589 cites W2065191374 @default.
• W1965995589 cites W2072952339 @default.
• W1965995589 cites W2078574800 @default.
• W1965995589 cites W2078839736 @default.
• W1965995589 cites W2086069830 @default.
• W1965995589 cites W2086250530 @default.
• W1965995589 cites W2087931340 @default.
• W1965995589 cites W2092125676 @default.
• W1965995589 cites W2095122176 @default.
• W1965995589 cites W2095634708 @default.
• W1965995589 cites W2096503457 @default.
• W1965995589 cites W2104647183 @default.
• W1965995589 cites W2145010618 @default.
• W1965995589 cites W2160593570 @default.
• W1965995589 cites W2168206768 @default.
• W1965995589 cites W2170885035 @default.
• W1965995589 cites W2402246919 @default.
• W1965995589 cites W95741617 @default.
• W1965995589 doi "https://doi.org/10.1016/j.biomaterials.2007.03.012" @default.
• W1965995589 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17428531" @default.
• W1965995589 hasPublicationYear "2007" @default.
• W1965995589 type Work @default.
• W1965995589 sameAs 1965995589 @default.
• W1965995589 citedByCount "78" @default.
• W1965995589 countsByYear W19659955892012 @default.
• W1965995589 countsByYear W19659955892013 @default.
• W1965995589 countsByYear W19659955892014 @default.
• W1965995589 countsByYear W19659955892015 @default.
• W1965995589 countsByYear W19659955892016 @default.
• W1965995589 countsByYear W19659955892017 @default.
• W1965995589 countsByYear W19659955892018 @default.
• W1965995589 countsByYear W19659955892019 @default.
• W1965995589 countsByYear W19659955892020 @default.
• W1965995589 countsByYear W19659955892021 @default.
• W1965995589 countsByYear W19659955892022 @default.
• W1965995589 countsByYear W19659955892023 @default.
• W1965995589 crossrefType "journal-article" @default.
• W1965995589 hasAuthorship W1965995589A5021090087 @default.
• W1965995589 hasAuthorship W1965995589A5086881309 @default.
• W1965995589 hasConcept C108586683 @default.
• W1965995589 hasConcept C109316439 @default.
• W1965995589 hasConcept C119394753 @default.
• W1965995589 hasConcept C12554922 @default.
• W1965995589 hasConcept C127413603 @default.
• W1965995589 hasConcept C159985019 @default.
• W1965995589 hasConcept C163588942 @default.
• W1965995589 hasConcept C171250308 @default.
• W1965995589 hasConcept C178790620 @default.
• W1965995589 hasConcept C181199279 @default.
• W1965995589 hasConcept C185592680 @default.
• W1965995589 hasConcept C188027245 @default.
• W1965995589 hasConcept C192562407 @default.
• W1965995589 hasConcept C193855658 @default.
• W1965995589 hasConcept C202751555 @default.
• W1965995589 hasConcept C2777230088 @default.
• W1965995589 hasConcept C2777318727 @default.
• W1965995589 hasConcept C42360764 @default.
• W1965995589 hasConcept C55493867 @default.
• W1965995589 hasConcept C55637122 @default.
• W1965995589 hasConcept C86803240 @default.
• W1965995589 hasConceptScore W1965995589C108586683 @default.
• W1965995589 hasConceptScore W1965995589C109316439 @default.
• W1965995589 hasConceptScore W1965995589C119394753 @default.
• W1965995589 hasConceptScore W1965995589C12554922 @default.
• W1965995589 hasConceptScore W1965995589C127413603 @default.
• W1965995589 hasConceptScore W1965995589C159985019 @default.
• W1965995589 hasConceptScore W1965995589C163588942 @default.
• W1965995589 hasConceptScore W1965995589C171250308 @default.
• W1965995589 hasConceptScore W1965995589C178790620 @default.
• W1965995589 hasConceptScore W1965995589C181199279 @default.

• next