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- W1965997423 abstract "The coexistence of two neuronally-localised peptides, substance P and thyrotropin-releasing hormone (TRH), in descending serotoninergic nerve fibres to the spinal cord was investigated using immunocytochemical and biochemical methods. Substance P-like material in the spinal cord was shown to be identical to the undecapeptide substance P by the criteria of gel filtration, high performance liquid chromatography and behaviour in substance P specific radioimmunoassays. Immunocytochemical staining for 5-hydroxytryptamine, substance P, and TRH showed that all three substances had a similar distribution in nerve fibres and terminals in the ventral and lateral grey matter of the spinal cord. After treatment with the serotonin neurotoxin 5,7-dihydroxytryptamine, neuronal elements containing 5-hydroxytryptamine, substance P and TRH degenerated and disappeared from these parts of the spinal cord in parallel with one another. Biochemical measurements of 5-hydroxytryptamine, substance P and TRH in the spinal cord after treatment with 5,7-dihydroxytryptamine confirmed that these three substances were all depleted from the ventral horn and, in addition, showed that there was a small depletion of substance P from the dorsal horn. Two other neuropeptides, somatostatin and methionine-enkephalin were not depleted from the spinal cord by treatment with 5,7-dihydroxytryptamine nor was substance P in other parts of the brain. Substance P in the spinal cord was unaffected by 6-hydroxydopamine, a drug known to destroy catecholamine-containing neurones. These results are consistent with coexistence of substance P and TRH together with 5-hydroxytryptamine in the descending axons and terminals of bulbospinal neurones." @default.
- W1965997423 created "2016-06-24" @default.
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- W1965997423 date "1982-01-01" @default.
- W1965997423 modified "2023-09-23" @default.
- W1965997423 title "The effects of monoamine neurotoxins on peptides in the rat spinal cord" @default.
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- W1965997423 cites W1968160865 @default.
- W1965997423 cites W1971926359 @default.
- W1965997423 cites W1972021568 @default.
- W1965997423 cites W1973241854 @default.
- W1965997423 cites W1974164498 @default.
- W1965997423 cites W1974782548 @default.
- W1965997423 cites W1976972192 @default.
- W1965997423 cites W1977080308 @default.
- W1965997423 cites W1977294562 @default.
- W1965997423 cites W1978238621 @default.
- W1965997423 cites W1979067055 @default.
- W1965997423 cites W1980271135 @default.
- W1965997423 cites W1984468353 @default.
- W1965997423 cites W1987074701 @default.
- W1965997423 cites W1990241746 @default.
- W1965997423 cites W1999774778 @default.
- W1965997423 cites W2002287054 @default.
- W1965997423 cites W2003405176 @default.
- W1965997423 cites W2004624137 @default.
- W1965997423 cites W2006497440 @default.
- W1965997423 cites W2011113908 @default.
- W1965997423 cites W2014077765 @default.
- W1965997423 cites W2014352149 @default.
- W1965997423 cites W2015152746 @default.
- W1965997423 cites W2015768769 @default.
- W1965997423 cites W2018068838 @default.
- W1965997423 cites W2018831181 @default.
- W1965997423 cites W2019244105 @default.
- W1965997423 cites W2020460680 @default.
- W1965997423 cites W2023117233 @default.
- W1965997423 cites W2023783180 @default.
- W1965997423 cites W2025477120 @default.
- W1965997423 cites W2026258328 @default.
- W1965997423 cites W2028277298 @default.
- W1965997423 cites W2031682264 @default.
- W1965997423 cites W2032467861 @default.
- W1965997423 cites W2032604602 @default.
- W1965997423 cites W2032746351 @default.
- W1965997423 cites W2032895441 @default.
- W1965997423 cites W2033779036 @default.
- W1965997423 cites W2035096039 @default.
- W1965997423 cites W2037411657 @default.
- W1965997423 cites W2040181384 @default.
- W1965997423 cites W2042038355 @default.
- W1965997423 cites W2042198076 @default.
- W1965997423 cites W2042543545 @default.
- W1965997423 cites W2045141981 @default.
- W1965997423 cites W2047054609 @default.
- W1965997423 cites W2050648713 @default.
- W1965997423 cites W2051438433 @default.
- W1965997423 cites W2053409748 @default.
- W1965997423 cites W2053472176 @default.
- W1965997423 cites W2055359049 @default.
- W1965997423 cites W2056672572 @default.
- W1965997423 cites W2058724157 @default.
- W1965997423 cites W2058977564 @default.
- W1965997423 cites W2061475155 @default.
- W1965997423 cites W2070868453 @default.
- W1965997423 cites W2073073327 @default.
- W1965997423 cites W2077755865 @default.
- W1965997423 cites W2079355643 @default.
- W1965997423 cites W2080641976 @default.
- W1965997423 cites W2081253940 @default.
- W1965997423 cites W2086483799 @default.
- W1965997423 cites W2086704144 @default.
- W1965997423 cites W2090389394 @default.
- W1965997423 cites W2090394414 @default.
- W1965997423 cites W2090618990 @default.
- W1965997423 cites W2090951611 @default.
- W1965997423 cites W2092990835 @default.
- W1965997423 cites W2093748427 @default.
- W1965997423 cites W2094175418 @default.
- W1965997423 cites W2101459312 @default.
- W1965997423 cites W2110151983 @default.
- W1965997423 cites W2132936307 @default.
- W1965997423 cites W2135112754 @default.
- W1965997423 cites W2144897859 @default.
- W1965997423 cites W2153292899 @default.
- W1965997423 cites W2887092660 @default.
- W1965997423 cites W4211008542 @default.
- W1965997423 doi "https://doi.org/10.1016/0306-4522(82)90154-3" @default.
- W1965997423 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6176903" @default.
- W1965997423 hasPublicationYear "1982" @default.
- W1965997423 type Work @default.