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• W1965997788 abstract "The yellow fever virus 17D vaccine strain is one of the most effective and safe vaccines available. The immune response after immunization is characterized by long-lasting high titers of neutralizing antibodies. Here, we have initiated a characterization of YFV-17D-specific cellular immune responses. This study makes three points. First, we have identified two CD8 T cell epitopes and one CD4 T cell epitope. An H-2K b -restricted dominant epitope was mapped in the NS3 protein, whereas the viral envelope protein harbored an H-2D b -restricted subdominant epitope and the I-A b -restricted CD4 T cell epitope. Second, illustrating the concept of immunodomination, we found that after abrogation of the dominant response in H-2K b knockout mice, the frequencies of T cells recognizing the subdominant D b -restricted epitope increased dramatically. Finally, the H-2D b -restricted epitope lacks the canonical Asn anchor residue at position 5, indicating that epitopes may be missed by strict application of the H-2D b -binding motif. Identification of these T cell epitopes will facilitate studies on the cellular immunity against YFV-based expression or immunization vectors." @default.
• W1965997788 created "2016-06-24" @default.
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• W1965997788 date "2002-04-01" @default.
• W1965997788 modified "2023-09-29" @default.
• W1965997788 title "Yellow Fever Virus 17D Envelope and NS3 Proteins Are Major Targets of the Antiviral T Cell Response in Mice" @default.
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• W1965997788 doi "https://doi.org/10.1006/viro.2002.1432" @default.
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