Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966003712> ?p ?o ?g. }
- W1966003712 endingPage "2480" @default.
- W1966003712 startingPage "2476" @default.
- W1966003712 abstract "Sheep are the natural hosts of the pathogens that cause scrapie, an infectious degenerative disease of the central nervous system. Scrapie-associated fibrils [and their major protein, prion protein (PrP)] accumulate in the brains of all species affected by scrapie and related diseases. PrP is encoded by a single gene that is linked to (and may be) the major gene controlling the incubation period of the various strains of scrapie pathogens. To investigate the role of PrP in natural scrapie, we have determined its gene structure and expression in the natural host. We have isolated two sheep genomic DNA clones that encode proteins of 256 amino acids with high homology to the PrPs of other species. Sheep PrPs have an arginine/glutamine polymorphism at position 171 that may be related to the alleles of the scrapie incubation-control gene in this species." @default.
- W1966003712 created "2016-06-24" @default.
- W1966003712 creator A5006806040 @default.
- W1966003712 creator A5017463196 @default.
- W1966003712 creator A5036033309 @default.
- W1966003712 creator A5064378943 @default.
- W1966003712 creator A5081287874 @default.
- W1966003712 creator A5081734448 @default.
- W1966003712 date "1990-04-01" @default.
- W1966003712 modified "2023-10-13" @default.
- W1966003712 title "Two alleles of a neural protein gene linked to scrapie in sheep." @default.
- W1966003712 cites W1500847022 @default.
- W1966003712 cites W1559478955 @default.
- W1966003712 cites W171398818 @default.
- W1966003712 cites W1784563469 @default.
- W1966003712 cites W1965051773 @default.
- W1966003712 cites W1965755240 @default.
- W1966003712 cites W1968102722 @default.
- W1966003712 cites W1973758214 @default.
- W1966003712 cites W1976767726 @default.
- W1966003712 cites W1980735475 @default.
- W1966003712 cites W1981931122 @default.
- W1966003712 cites W1990497827 @default.
- W1966003712 cites W2003676486 @default.
- W1966003712 cites W2006238316 @default.
- W1966003712 cites W2009310436 @default.
- W1966003712 cites W2014669590 @default.
- W1966003712 cites W2014742609 @default.
- W1966003712 cites W2018407130 @default.
- W1966003712 cites W2021505439 @default.
- W1966003712 cites W2025450446 @default.
- W1966003712 cites W2032446305 @default.
- W1966003712 cites W2032462421 @default.
- W1966003712 cites W2032584367 @default.
- W1966003712 cites W2033917233 @default.
- W1966003712 cites W2035379431 @default.
- W1966003712 cites W2037069965 @default.
- W1966003712 cites W2043979078 @default.
- W1966003712 cites W2047043554 @default.
- W1966003712 cites W2051968416 @default.
- W1966003712 cites W2053452111 @default.
- W1966003712 cites W2053636966 @default.
- W1966003712 cites W2060333964 @default.
- W1966003712 cites W2065983662 @default.
- W1966003712 cites W2066160869 @default.
- W1966003712 cites W2072296425 @default.
- W1966003712 cites W2082438097 @default.
- W1966003712 cites W2082936458 @default.
- W1966003712 cites W2084773650 @default.
- W1966003712 cites W2086996663 @default.
- W1966003712 cites W2110420813 @default.
- W1966003712 cites W2124137042 @default.
- W1966003712 cites W2129323684 @default.
- W1966003712 cites W2132697588 @default.
- W1966003712 cites W2138270253 @default.
- W1966003712 cites W2141839336 @default.
- W1966003712 cites W2156129054 @default.
- W1966003712 cites W2225090831 @default.
- W1966003712 cites W2341167346 @default.
- W1966003712 cites W4239669946 @default.
- W1966003712 cites W6513890 @default.
- W1966003712 doi "https://doi.org/10.1073/pnas.87.7.2476" @default.
- W1966003712 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/53712" @default.
- W1966003712 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1969635" @default.
- W1966003712 hasPublicationYear "1990" @default.
- W1966003712 type Work @default.
- W1966003712 sameAs 1966003712 @default.
- W1966003712 citedByCount "283" @default.
- W1966003712 countsByYear W19660037122012 @default.
- W1966003712 countsByYear W19660037122013 @default.
- W1966003712 countsByYear W19660037122014 @default.
- W1966003712 countsByYear W19660037122015 @default.
- W1966003712 countsByYear W19660037122016 @default.
- W1966003712 countsByYear W19660037122017 @default.
- W1966003712 countsByYear W19660037122018 @default.
- W1966003712 countsByYear W19660037122019 @default.
- W1966003712 countsByYear W19660037122020 @default.
- W1966003712 countsByYear W19660037122021 @default.
- W1966003712 countsByYear W19660037122022 @default.
- W1966003712 countsByYear W19660037122023 @default.
- W1966003712 crossrefType "journal-article" @default.
- W1966003712 hasAuthorship W1966003712A5006806040 @default.
- W1966003712 hasAuthorship W1966003712A5017463196 @default.
- W1966003712 hasAuthorship W1966003712A5036033309 @default.
- W1966003712 hasAuthorship W1966003712A5064378943 @default.
- W1966003712 hasAuthorship W1966003712A5081287874 @default.
- W1966003712 hasAuthorship W1966003712A5081734448 @default.
- W1966003712 hasBestOaLocation W19660037122 @default.
- W1966003712 hasConcept C104317684 @default.
- W1966003712 hasConcept C142724271 @default.
- W1966003712 hasConcept C150194340 @default.
- W1966003712 hasConcept C159047783 @default.
- W1966003712 hasConcept C165525559 @default.
- W1966003712 hasConcept C180754005 @default.
- W1966003712 hasConcept C2776735649 @default.
- W1966003712 hasConcept C2779134260 @default.
- W1966003712 hasConcept C3019804061 @default.
- W1966003712 hasConcept C54355233 @default.