FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966004273> ?p ?o ?g. }

• W1966004273 endingPage "2476" @default.
• W1966004273 startingPage "2469" @default.
• W1966004273 abstract "Traumatic injury to the spinal cord initiates a host of pathophysiological events that are secondary to the initial insult. One such event is the accumulation of free radicals that damage lipids, proteins, and nucleic acids. A major reactive product formed following lipid peroxidation is the aldehyde, 4-hydroxynonenal (HNE), which cross-links to side chain amino acids and inhibits the function of several key metabolic enzymes. In the present study, we used immunocytochemical and immunoblotting techniques to examine the accumulation of protein-bound HNE, and synaptosomal preparations to study the effects of spinal cord injury and HNE formation on glutamate uptake. Protein-bound HNE increased in content in the damaged spinal cord at early times following injury (1-24 h) and was found to accumulate in myelinated fibers distant to the site of injury. Immunoblots revealed that protein-bound HNE levels increased dramatically over the same postinjury interval. Glutamate uptake in synaptosomal preparations from injured spinal cords was decreased by 65% at 24 h following injury. Treatment of control spinal cord synaptosomes with HNE was found to decrease significantly, in a dose-dependent fashion, glutamate uptake, an effect that was mimicked by inducers of lipid peroxidation. Taken together, these findings demonstrate that the lipid peroxidation product HNE rapidly accumulates in the spinal cord following injury and that a major consequence of HNE accumulation is a decrease in glutamate uptake, which may potentiate neuronal cell dysfunction and death through excitotoxic mechanisms." @default.
• W1966004273 created "2016-06-24" @default.
• W1966004273 creator A5015316751 @default.
• W1966004273 creator A5020019357 @default.
• W1966004273 creator A5054196760 @default.
• W1966004273 creator A5070237792 @default.
• W1966004273 creator A5083040475 @default.
• W1966004273 creator A5087754116 @default.
• W1966004273 date "2002-11-18" @default.
• W1966004273 modified "2023-10-14" @default.
• W1966004273 title "4-Hydroxynonenal, a Lipid Peroxidation Product, Rapidly Accumulates Following Traumatic Spinal Cord Injury and Inhibits Glutamate Uptake" @default.
• W1966004273 cites W133907179 @default.
• W1966004273 cites W1491358295 @default.
• W1966004273 cites W1503545438 @default.
• W1966004273 cites W1506990787 @default.
• W1966004273 cites W1507242444 @default.
• W1966004273 cites W1516370311 @default.
• W1966004273 cites W1654460714 @default.
• W1966004273 cites W1891884171 @default.
• W1966004273 cites W1900227502 @default.
• W1966004273 cites W1909841186 @default.
• W1966004273 cites W1964094293 @default.
• W1966004273 cites W1964613272 @default.
• W1966004273 cites W1969912167 @default.
• W1966004273 cites W1970972003 @default.
• W1966004273 cites W1975114770 @default.
• W1966004273 cites W1975139578 @default.
• W1966004273 cites W1978348298 @default.
• W1966004273 cites W1985075855 @default.
• W1966004273 cites W2000243807 @default.
• W1966004273 cites W2003410399 @default.
• W1966004273 cites W2011971949 @default.
• W1966004273 cites W2014091183 @default.
• W1966004273 cites W2014094971 @default.
• W1966004273 cites W2015268116 @default.
• W1966004273 cites W2016293448 @default.
• W1966004273 cites W2029545906 @default.
• W1966004273 cites W2040751295 @default.
• W1966004273 cites W2046286708 @default.
• W1966004273 cites W2050746675 @default.
• W1966004273 cites W2057866248 @default.
• W1966004273 cites W2065264404 @default.
• W1966004273 cites W2072918771 @default.
• W1966004273 cites W2084861237 @default.
• W1966004273 cites W2094038479 @default.
• W1966004273 cites W2096194292 @default.
• W1966004273 cites W2116234096 @default.
• W1966004273 cites W2121050534 @default.
• W1966004273 cites W2150403676 @default.
• W1966004273 cites W2155569675 @default.
• W1966004273 cites W2155747798 @default.
• W1966004273 cites W2160353065 @default.
• W1966004273 cites W2162488829 @default.
• W1966004273 cites W2162537209 @default.
• W1966004273 cites W312472794 @default.
• W1966004273 cites W3152410314 @default.
• W1966004273 doi "https://doi.org/10.1046/j.1471-4159.1997.68062469.x" @default.
• W1966004273 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9166741" @default.
• W1966004273 hasPublicationYear "2002" @default.
• W1966004273 type Work @default.
• W1966004273 sameAs 1966004273 @default.
• W1966004273 citedByCount "184" @default.
• W1966004273 countsByYear W19660042732012 @default.
• W1966004273 countsByYear W19660042732013 @default.
• W1966004273 countsByYear W19660042732014 @default.
• W1966004273 countsByYear W19660042732015 @default.
• W1966004273 countsByYear W19660042732016 @default.
• W1966004273 countsByYear W19660042732017 @default.
• W1966004273 countsByYear W19660042732018 @default.
• W1966004273 countsByYear W19660042732019 @default.
• W1966004273 countsByYear W19660042732020 @default.
• W1966004273 countsByYear W19660042732021 @default.
• W1966004273 countsByYear W19660042732022 @default.
• W1966004273 countsByYear W19660042732023 @default.
• W1966004273 crossrefType "journal-article" @default.
• W1966004273 hasAuthorship W1966004273A5015316751 @default.
• W1966004273 hasAuthorship W1966004273A5020019357 @default.
• W1966004273 hasAuthorship W1966004273A5054196760 @default.
• W1966004273 hasAuthorship W1966004273A5070237792 @default.
• W1966004273 hasAuthorship W1966004273A5083040475 @default.
• W1966004273 hasAuthorship W1966004273A5087754116 @default.
• W1966004273 hasConcept C126322002 @default.
• W1966004273 hasConcept C134018914 @default.
• W1966004273 hasConcept C169760540 @default.
• W1966004273 hasConcept C170493617 @default.
• W1966004273 hasConcept C185592680 @default.
• W1966004273 hasConcept C2776151105 @default.
• W1966004273 hasConcept C2778334475 @default.
• W1966004273 hasConcept C2779308327 @default.
• W1966004273 hasConcept C2780775167 @default.
• W1966004273 hasConcept C2780829032 @default.
• W1966004273 hasConcept C55493867 @default.
• W1966004273 hasConcept C61174792 @default.
• W1966004273 hasConcept C71924100 @default.
• W1966004273 hasConcept C86803240 @default.
• W1966004273 hasConceptScore W1966004273C126322002 @default.
• W1966004273 hasConceptScore W1966004273C134018914 @default.
• W1966004273 hasConceptScore W1966004273C169760540 @default.

• next