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- W1966008657 abstract "During the past year, major progress has been made in understanding proximal TCR signal-transduction events. Cbl has been identified as a negative regulator of kinases from the ZAP-70/Syk family. Studies on LAT, SLP-76, Itk and Vav have revealed their role in the activation of Ras and phospholipase-Cγ 1-Ca2+ signalling pathways. TCR-induced cytoskeletal changes involve signalling through SLP-76-Vav-Nck to activate effectors of the Rho-family of GTPases. Finally, glycolipidenriched microdomains play a crucial role in T cell activation." @default.
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- W1966008657 date "1999-06-01" @default.
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- W1966008657 title "T cell antigen-receptor signal transduction" @default.
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- W1966008657 doi "https://doi.org/10.1016/s0952-7915(99)80040-5" @default.
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