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- W1966009391 abstract "SUMMARY Isolates of the oomycete Phytophthora infestans exhibit a wide range of intrinsic sensitivities to fungicides, which potentially influences the application rates of chemicals needed to control potato late blight. To help understand what determines such levels of sensitivity, a genetic approach was employed which followed the segregation of sensitivities to structurally diverse fungicides such as metalaxyl and trifloxystrobin. Progeny exhibited broad distributions of sensitivity phenotypes, consistent with the behaviour of a quantitative trait. Measurements of the inhibition of strains by seven fungicides revealed that basal sensitivities to metalaxyl and trifloxystrobin, and to cymoxanil and dimethomorph, correlated at the 95% confidence level. These compounds have distinct modes of action, suggesting the involvement of a multifungicide efflux phenomenon mediated by ABC transporters. To determine whether such proteins contribute to variation in sensitivity, 41 full transporters and 13 half transporters were identified from P. infestans and their mRNA levels compared in strains exhibiting higher or lower sensitivities to fungicides. No correlation was observed between the expression of any ABC transporter and fungicide sensitivity. Other genes, or variation in the activities of the transporters, may therefore explain the differences between strains. Five ABC transporters were induced by several fungicides in strains with both higher and lower sensitivities to fungicides, which probably reflects the existence of a network for protecting against natural and artificial toxins." @default.
- W1966009391 created "2016-06-24" @default.
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- W1966009391 date "2005-11-23" @default.
- W1966009391 modified "2023-10-15" @default.
- W1966009391 title "Investigating the role of ABC transporters in multifungicide insensitivity in Phytophthora infestans" @default.
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- W1966009391 doi "https://doi.org/10.1111/j.1364-3703.2004.00256.x-i1" @default.
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