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- W1966010392 abstract "Interleukin-1 receptor antagonist (IL-1Ra) inhibits the classical biological effects of interleukin (IL)-1 by preventing its binding to IL-1 receptors. There are, however, four different isoforms of IL-1Ra, of which three are intracellular (icIL-1Ra1, 2, 3). Due to their localization, icIL-1Ras cannot interact with cell surface IL-1 receptors and have been suggested to carry out specific functions inside cells. The recent description of nuclear effects of the IL-1α precursor (preIL-1α) led to the hypothesis that icIL-1Ra variants might antagonize the intracellular actions of preIL-1α. The aim of this study was to investigate effects of preIL-1α and icIL-1Ra1 in stably transfected SaOS-2 cells. Expression of preIL-1α significantly decreased cell growth and this effect was not reversed by addition of exogenous IL-1Ra, suggesting an intracellular mode of action. Transfection of SaOS-2 cells with icIL-1Ra1 did not affect their growth. Furthermore, co-expression of icIL-1Ra1 did not reverse the growth inhibitory effect of preIL-1α. In contrast, the production of IL-6 induced by preIL-1α was decreased in icIL-1Ra1 co-transfected cells. In conclusion, expression of preIL-1α decreased the growth of SaOS-2 cells, likely by an intracellular mechanism. Co-expression of icIL-1Ra1 did not antagonize this effect, indicating that intracellular effects of preIL-1α are not necessarily susceptible to inhibition by icIL-1Ra1." @default.
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- W1966010392 date "2005-07-21" @default.
- W1966010392 modified "2023-10-12" @default.
- W1966010392 title "Pre-interleukin-1α expression reduces cell growth and increases interleukin-6 production in SaOS-2 osteosarcoma cells: Differential inhibitory effect of interleukin-1 receptor antagonist (icIL-1Ra1)" @default.
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- W1966010392 doi "https://doi.org/10.1016/j.cyto.2005.03.007" @default.
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