Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966014623> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W1966014623 endingPage "381" @default.
- W1966014623 startingPage "373" @default.
- W1966014623 abstract "Bioactivation of diaziquone (AZQ) in HT-29 human colon carcinoma cells and detoxification of benzene metabolites in bone marrow stromal cells were used as examples of the potential role of DT-diaphorase in both activation and deactivation processes. HT-29 cell cytosol contained high levels of DT-diaphorase activity and removed AZQ in the presence of either NADH or NADPH. Prior boiling of cytosol. omission of NADH or NADPH or inclusion of dicoumarol. an inhibitor of DT-diaphorase. inhibited removal of AZQ. AZQ-inouced cytotoxicity in HT-29 cells was also inhibited by dicoumarol. Chemical reduction of AZQ in a cell free system enhanced formation of a GSH conjugate of AZQ. Two of the major cell types in bone marrow stroma are macrophages and fibroblastoid stromal cells. A fibroblastoid cell line derived from stromal cells contained approximately fourfold higher levels of DT-diaphorase than macrophages. Inclusion of dicournarol in incubations containing 14C-hydroquinone and the respective stromal cell type, significantly increased covalent binding of radiolabel to macromolecules in stromal fibroblasts but not in macrophages" @default.
- W1966014623 created "2016-06-24" @default.
- W1966014623 creator A5001448342 @default.
- W1966014623 creator A5017502618 @default.
- W1966014623 creator A5024622700 @default.
- W1966014623 creator A5054336361 @default.
- W1966014623 creator A5064985882 @default.
- W1966014623 creator A5089738784 @default.
- W1966014623 creator A5090177003 @default.
- W1966014623 date "1990-01-01" @default.
- W1966014623 modified "2023-09-26" @default.
- W1966014623 title "Activation And Deactivation Of Quinones Catalyzed By Dt-Diaphorase. Evidence For Bioreductive Activation Of Diaziquone (Azq) In Human Tumor Cells And Detoxification Of Benzene Metabolites In Bone Marrow Stroma" @default.
- W1966014623 cites W112949929 @default.
- W1966014623 cites W1595656597 @default.
- W1966014623 cites W1964004127 @default.
- W1966014623 cites W1993654673 @default.
- W1966014623 cites W2002314190 @default.
- W1966014623 cites W2004248446 @default.
- W1966014623 cites W2021236154 @default.
- W1966014623 cites W2053536319 @default.
- W1966014623 cites W2071956026 @default.
- W1966014623 cites W2073587530 @default.
- W1966014623 cites W2076052186 @default.
- W1966014623 cites W2082561811 @default.
- W1966014623 cites W2082619145 @default.
- W1966014623 cites W2083970157 @default.
- W1966014623 cites W2158788457 @default.
- W1966014623 cites W956554017 @default.
- W1966014623 doi "https://doi.org/10.3109/10715769009053371" @default.
- W1966014623 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2113030" @default.
- W1966014623 hasPublicationYear "1990" @default.
- W1966014623 type Work @default.
- W1966014623 sameAs 1966014623 @default.
- W1966014623 citedByCount "47" @default.
- W1966014623 countsByYear W19660146232012 @default.
- W1966014623 countsByYear W19660146232020 @default.
- W1966014623 crossrefType "journal-article" @default.
- W1966014623 hasAuthorship W1966014623A5001448342 @default.
- W1966014623 hasAuthorship W1966014623A5017502618 @default.
- W1966014623 hasAuthorship W1966014623A5024622700 @default.
- W1966014623 hasAuthorship W1966014623A5054336361 @default.
- W1966014623 hasAuthorship W1966014623A5064985882 @default.
- W1966014623 hasAuthorship W1966014623A5089738784 @default.
- W1966014623 hasAuthorship W1966014623A5090177003 @default.
- W1966014623 hasConcept C109316439 @default.
- W1966014623 hasConcept C16930146 @default.
- W1966014623 hasConcept C181199279 @default.
- W1966014623 hasConcept C185592680 @default.
- W1966014623 hasConcept C202751555 @default.
- W1966014623 hasConcept C2777990912 @default.
- W1966014623 hasConcept C502942594 @default.
- W1966014623 hasConcept C54355233 @default.
- W1966014623 hasConcept C55493867 @default.
- W1966014623 hasConcept C75520062 @default.
- W1966014623 hasConcept C81885089 @default.
- W1966014623 hasConcept C86803240 @default.
- W1966014623 hasConcept C98539663 @default.
- W1966014623 hasConceptScore W1966014623C109316439 @default.
- W1966014623 hasConceptScore W1966014623C16930146 @default.
- W1966014623 hasConceptScore W1966014623C181199279 @default.
- W1966014623 hasConceptScore W1966014623C185592680 @default.
- W1966014623 hasConceptScore W1966014623C202751555 @default.
- W1966014623 hasConceptScore W1966014623C2777990912 @default.
- W1966014623 hasConceptScore W1966014623C502942594 @default.
- W1966014623 hasConceptScore W1966014623C54355233 @default.
- W1966014623 hasConceptScore W1966014623C55493867 @default.
- W1966014623 hasConceptScore W1966014623C75520062 @default.
- W1966014623 hasConceptScore W1966014623C81885089 @default.
- W1966014623 hasConceptScore W1966014623C86803240 @default.
- W1966014623 hasConceptScore W1966014623C98539663 @default.
- W1966014623 hasIssue "4-6" @default.
- W1966014623 hasLocation W19660146231 @default.
- W1966014623 hasLocation W19660146232 @default.
- W1966014623 hasOpenAccess W1966014623 @default.
- W1966014623 hasPrimaryLocation W19660146231 @default.
- W1966014623 hasRelatedWork W1753158170 @default.
- W1966014623 hasRelatedWork W1983151148 @default.
- W1966014623 hasRelatedWork W1986715413 @default.
- W1966014623 hasRelatedWork W2014562974 @default.
- W1966014623 hasRelatedWork W2040591614 @default.
- W1966014623 hasRelatedWork W2067883879 @default.
- W1966014623 hasRelatedWork W2117202948 @default.
- W1966014623 hasRelatedWork W4492010 @default.
- W1966014623 hasRelatedWork W2116860795 @default.
- W1966014623 hasRelatedWork W2739218524 @default.
- W1966014623 hasVolume "8" @default.
- W1966014623 isParatext "false" @default.
- W1966014623 isRetracted "false" @default.
- W1966014623 magId "1966014623" @default.
- W1966014623 workType "article" @default.