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• W1966015910 startingPage "44" @default.
• W1966015910 abstract "A female-sterile zebrafish maternal-effect mutation in cellular atoll (cea) results in defects in the initiation of cell division starting at the second cell division cycle. This phenomenon is caused by defects in centrosome duplication, which in turn affect the formation of a bipolar spindle. We show that cea encodes the centriolar coiled-coil protein Sas-6, and that zebrafish Cea/Sas-6 protein localizes to centrosomes. cea also has a genetic paternal contribution, which when mutated results in an arrested first cell division followed by normal cleavage. Our data supports the idea that, in zebrafish, paternally inherited centrosomes are required for the first cell division while maternally derived factors are required for centrosomal duplication and cell divisions in subsequent cell cycles. DNA synthesis ensues in the absence of centrosome duplication, and the one-cycle delay in the first cell division caused by cea mutant sperm leads to whole genome duplication. We discuss the potential implications of these findings with regards to the origin of polyploidization in animal species. In addition, the uncoupling of developmental time and cell division count caused by the cea mutation suggests the presence of a time window, normally corresponding to the first two cell cycles, which is permissive for germ plasm recruitment." @default.
• W1966015910 created "2016-06-24" @default.
• W1966015910 creator A5044847165 @default.
• W1966015910 creator A5058011833 @default.
• W1966015910 creator A5063901125 @default.
• W1966015910 date "2007-12-01" @default.
• W1966015910 modified "2023-10-03" @default.
• W1966015910 title "The zebrafish maternal-effect gene cellular atoll encodes the centriolar component sas-6 and defects in its paternal function promote whole genome duplication" @default.
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• W1966015910 doi "https://doi.org/10.1016/j.ydbio.2007.08.054" @default.
• W1966015910 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2693064" @default.
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