FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966027709> ?p ?o ?g. }

• W1966027709 endingPage "125" @default.
• W1966027709 startingPage "117" @default.
• W1966027709 abstract "Melanoma tumor antigens, MAGE-1 and -3 are presented on HLA-A1 and -Cw*1601, or -A1 and -A2, respectively, to the corresponding cytotoxic T lymphocytes (CTL). If CTL recognizing these antigens were generated in patients, clones of positive tumor cells should be eliminated. To ascertain whether such an immunological response is active in patients with lung cancer and to determine what fraction of lung cancer patients are candidates for MAGE oriented immunotherapy, we assessed the relationship between HLA-A1 or -A2 expression and MAGE-1 or -3 gene expression in their tumors. MAGE-1 and -3 were detected in 18/55 (33%) and 23/55 (42%), respectively, by reverse transcriptase (RT)-polymerase chain reaction (PCR). Allele specific PCR revealed HLA-A1 and -A2 alleles to be expressed in 0/55 (0%) and 22/55 (40%) of our cohort, respectively. Among the 22 patients with HLA-A2 genotype, expression of HLA class I antigens detectable by immunohistochemistry was lost in five (23%) cases. The frequency of MAGE-3 expression in HLA-A2 patients was 5/17 (29%), somewhat lower than that of patients without HLA-A2 expression, 18/38 (47%), although the difference was not statistically significant (P=0.17). Neither was there a significant association between HLA-A2/MAGE-3 co-expression and survival (P=0.15, logrank test). We conclude that there is no clear evidence for elimination of lung cancers co-expressing HLA-A2 and MAGE-3 in vivo. Approximately 10% (5/55) of Japanese lung cancer patients are potential candidates for MAGE-3-based immunotherapy." @default.
• W1966027709 created "2016-06-24" @default.
• W1966027709 creator A5005497931 @default.
• W1966027709 creator A5023903693 @default.
• W1966027709 creator A5039145513 @default.
• W1966027709 creator A5059955082 @default.
• W1966027709 creator A5061491407 @default.
• W1966027709 creator A5076139883 @default.
• W1966027709 creator A5081110935 @default.
• W1966027709 creator A5090236371 @default.
• W1966027709 date "1998-05-01" @default.
• W1966027709 modified "2023-10-17" @default.
• W1966027709 title "Frequency of MAGE-3 gene expression in HLA-A2 positive patients with non-small cell lung cancer" @default.
• W1966027709 cites W1670921079 @default.
• W1966027709 cites W1977273255 @default.
• W1966027709 cites W1981487717 @default.
• W1966027709 cites W1998121016 @default.
• W1966027709 cites W2006987944 @default.
• W1966027709 cites W2018227907 @default.
• W1966027709 cites W2024061385 @default.
• W1966027709 cites W2026970642 @default.
• W1966027709 cites W2030005722 @default.
• W1966027709 cites W2041407734 @default.
• W1966027709 cites W2054168466 @default.
• W1966027709 cites W2073252143 @default.
• W1966027709 cites W2073520179 @default.
• W1966027709 cites W2086213587 @default.
• W1966027709 cites W2096428903 @default.
• W1966027709 cites W2103973613 @default.
• W1966027709 cites W2107389149 @default.
• W1966027709 cites W2117080326 @default.
• W1966027709 cites W2148368831 @default.
• W1966027709 cites W2149940155 @default.
• W1966027709 cites W2154464696 @default.
• W1966027709 cites W2155765223 @default.
• W1966027709 cites W2161343890 @default.
• W1966027709 cites W4293241248 @default.
• W1966027709 doi "https://doi.org/10.1016/s0169-5002(98)00017-8" @default.
• W1966027709 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/9711530" @default.
• W1966027709 hasPublicationYear "1998" @default.
• W1966027709 type Work @default.
• W1966027709 sameAs 1966027709 @default.
• W1966027709 citedByCount "29" @default.
• W1966027709 countsByYear W19660277092012 @default.
• W1966027709 countsByYear W19660277092013 @default.
• W1966027709 countsByYear W19660277092014 @default.
• W1966027709 countsByYear W19660277092017 @default.
• W1966027709 countsByYear W19660277092018 @default.
• W1966027709 crossrefType "journal-article" @default.
• W1966027709 hasAuthorship W1966027709A5005497931 @default.
• W1966027709 hasAuthorship W1966027709A5023903693 @default.
• W1966027709 hasAuthorship W1966027709A5039145513 @default.
• W1966027709 hasAuthorship W1966027709A5059955082 @default.
• W1966027709 hasAuthorship W1966027709A5061491407 @default.
• W1966027709 hasAuthorship W1966027709A5076139883 @default.
• W1966027709 hasAuthorship W1966027709A5081110935 @default.
• W1966027709 hasAuthorship W1966027709A5090236371 @default.
• W1966027709 hasConcept C104317684 @default.
• W1966027709 hasConcept C121608353 @default.
• W1966027709 hasConcept C126322002 @default.
• W1966027709 hasConcept C135763542 @default.
• W1966027709 hasConcept C143998085 @default.
• W1966027709 hasConcept C147483822 @default.
• W1966027709 hasConcept C147969180 @default.
• W1966027709 hasConcept C154317977 @default.
• W1966027709 hasConcept C167672396 @default.
• W1966027709 hasConcept C188280979 @default.
• W1966027709 hasConcept C202751555 @default.
• W1966027709 hasConcept C203014093 @default.
• W1966027709 hasConcept C2776256026 @default.
• W1966027709 hasConcept C2777658100 @default.
• W1966027709 hasConcept C2777701055 @default.
• W1966027709 hasConcept C502942594 @default.
• W1966027709 hasConcept C54355233 @default.
• W1966027709 hasConcept C71924100 @default.
• W1966027709 hasConcept C86803240 @default.
• W1966027709 hasConceptScore W1966027709C104317684 @default.
• W1966027709 hasConceptScore W1966027709C121608353 @default.
• W1966027709 hasConceptScore W1966027709C126322002 @default.
• W1966027709 hasConceptScore W1966027709C135763542 @default.
• W1966027709 hasConceptScore W1966027709C143998085 @default.
• W1966027709 hasConceptScore W1966027709C147483822 @default.
• W1966027709 hasConceptScore W1966027709C147969180 @default.
• W1966027709 hasConceptScore W1966027709C154317977 @default.
• W1966027709 hasConceptScore W1966027709C167672396 @default.
• W1966027709 hasConceptScore W1966027709C188280979 @default.
• W1966027709 hasConceptScore W1966027709C202751555 @default.
• W1966027709 hasConceptScore W1966027709C203014093 @default.
• W1966027709 hasConceptScore W1966027709C2776256026 @default.
• W1966027709 hasConceptScore W1966027709C2777658100 @default.
• W1966027709 hasConceptScore W1966027709C2777701055 @default.
• W1966027709 hasConceptScore W1966027709C502942594 @default.
• W1966027709 hasConceptScore W1966027709C54355233 @default.
• W1966027709 hasConceptScore W1966027709C71924100 @default.
• W1966027709 hasConceptScore W1966027709C86803240 @default.
• W1966027709 hasIssue "2" @default.
• W1966027709 hasLocation W19660277091 @default.
• W1966027709 hasLocation W19660277092 @default.

• next