FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966043410> ?p ?o ?g. }

• W1966043410 endingPage "819" @default.
• W1966043410 startingPage "811" @default.
• W1966043410 abstract "Traumatic Brain Injury (TBI) is known to result in oxidative stress, and as variation at the Apolipoprotein E (APOE) gene has been shown to influence outcome following TBI, but through as yet unclear mechanisms, we used transgenic APOE mouse models to examine the relationship between APOE genotype and oxidative stress following TBI. We administered a controlled cortical impact (CCI) injury or sham injury to transgenic mice expressing either human APOE3 or APOE4 on a murine APOE-deficient background. RNA was prepared from the ipsilateral hippocampi and cortices retrieved at 24 h and 1 month post-TBI. Microarray analysis was performed on unpooled samples from three mice per group to determine the genomic response to TBI and to specifically investigate the response of genes involved in oxidative stress mechanisms. Our data demonstrated TBI-induced expression of many more anti-oxidant related genes in the APOE3 mice, suggesting a potential anti-oxidative role for ApoE3 compared to ApoE4. However, in an additional cohort of mice we isolated the ipsilateral hippocampi, cortices, and cerebella at 1 month after TBI or sham injury for immunohistochemical analysis of markers of oxidative stress: the formation and presence of carbonyls (indication of general oxidative modification), 3-nitrotyrosine (3NT; specific to protein modification), or 4-hydroxyl-2-nonenal (HNE; specific to lipid peroxidation). Although we observed significant increases in all three markers of oxidative stress in response to injury, and genotype was a significant factor for carbonyl and 3NT, we found no significant interaction between genotype and injury. This may be due to the overwhelming effect of injury compared to genotype in our ANOVA, but nonetheless suggests that an influence on oxidative stress response is not the primary mechanism behind the APOE-genotype dependent effects on outcome following TBI." @default.
• W1966043410 created "2016-06-24" @default.
• W1966043410 creator A5000824564 @default.
• W1966043410 creator A5004157232 @default.
• W1966043410 creator A5018495139 @default.
• W1966043410 creator A5025113795 @default.
• W1966043410 creator A5033609522 @default.
• W1966043410 creator A5041572326 @default.
• W1966043410 creator A5055437280 @default.
• W1966043410 creator A5059178363 @default.
• W1966043410 creator A5067454835 @default.
• W1966043410 creator A5070575293 @default.
• W1966043410 creator A5074389236 @default.
• W1966043410 creator A5075392671 @default.
• W1966043410 creator A5090773792 @default.
• W1966043410 date "2010-07-01" @default.
• W1966043410 modified "2023-09-26" @default.
• W1966043410 title "Apolipoprotein E genotype and oxidative stress response to traumatic brain injury" @default.
• W1966043410 cites W138990109 @default.
• W1966043410 cites W140178960 @default.
• W1966043410 cites W1532356318 @default.
• W1966043410 cites W177761841 @default.
• W1966043410 cites W1838909952 @default.
• W1966043410 cites W1965607606 @default.
• W1966043410 cites W1968930078 @default.
• W1966043410 cites W1973633053 @default.
• W1966043410 cites W1985859760 @default.
• W1966043410 cites W1988829300 @default.
• W1966043410 cites W1990142996 @default.
• W1966043410 cites W1996160406 @default.
• W1966043410 cites W2011199056 @default.
• W1966043410 cites W2013898334 @default.
• W1966043410 cites W2014399495 @default.
• W1966043410 cites W2015646091 @default.
• W1966043410 cites W2016422384 @default.
• W1966043410 cites W2020683729 @default.
• W1966043410 cites W2024148149 @default.
• W1966043410 cites W2033041218 @default.
• W1966043410 cites W2037864697 @default.
• W1966043410 cites W2041960583 @default.
• W1966043410 cites W2046556661 @default.
• W1966043410 cites W2053840148 @default.
• W1966043410 cites W2056631437 @default.
• W1966043410 cites W2058616111 @default.
• W1966043410 cites W2061243940 @default.
• W1966043410 cites W2062080431 @default.
• W1966043410 cites W2063723612 @default.
• W1966043410 cites W2063865866 @default.
• W1966043410 cites W2064919512 @default.
• W1966043410 cites W2081110690 @default.
• W1966043410 cites W2081122171 @default.
• W1966043410 cites W2083208710 @default.
• W1966043410 cites W2084646646 @default.
• W1966043410 cites W2086882156 @default.
• W1966043410 cites W2089292460 @default.
• W1966043410 cites W2097608504 @default.
• W1966043410 cites W2112818206 @default.
• W1966043410 cites W2112986223 @default.
• W1966043410 cites W2116047361 @default.
• W1966043410 cites W2123572537 @default.
• W1966043410 cites W2124793618 @default.
• W1966043410 cites W2125347758 @default.
• W1966043410 cites W2126375117 @default.
• W1966043410 cites W2127156887 @default.
• W1966043410 cites W2128526521 @default.
• W1966043410 cites W2133385476 @default.
• W1966043410 cites W2141024716 @default.
• W1966043410 cites W2141160897 @default.
• W1966043410 cites W2146373526 @default.
• W1966043410 cites W2149668250 @default.
• W1966043410 cites W2156215695 @default.
• W1966043410 cites W2163305295 @default.
• W1966043410 cites W2166483810 @default.
• W1966043410 cites W2172262465 @default.
• W1966043410 cites W2410232758 @default.
• W1966043410 doi "https://doi.org/10.1016/j.neuroscience.2010.01.031" @default.
• W1966043410 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20105454" @default.
• W1966043410 hasPublicationYear "2010" @default.
• W1966043410 type Work @default.
• W1966043410 sameAs 1966043410 @default.
• W1966043410 citedByCount "27" @default.
• W1966043410 countsByYear W19660434102012 @default.
• W1966043410 countsByYear W19660434102013 @default.
• W1966043410 countsByYear W19660434102014 @default.
• W1966043410 countsByYear W19660434102015 @default.
• W1966043410 countsByYear W19660434102016 @default.
• W1966043410 countsByYear W19660434102018 @default.
• W1966043410 countsByYear W19660434102019 @default.
• W1966043410 countsByYear W19660434102020 @default.
• W1966043410 countsByYear W19660434102022 @default.
• W1966043410 crossrefType "journal-article" @default.
• W1966043410 hasAuthorship W1966043410A5000824564 @default.
• W1966043410 hasAuthorship W1966043410A5004157232 @default.
• W1966043410 hasAuthorship W1966043410A5018495139 @default.
• W1966043410 hasAuthorship W1966043410A5025113795 @default.
• W1966043410 hasAuthorship W1966043410A5033609522 @default.
• W1966043410 hasAuthorship W1966043410A5041572326 @default.
• W1966043410 hasAuthorship W1966043410A5055437280 @default.

• next