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• W1966048528 abstract "The prokineticin system comprises two multifunctional secreted proteins, prokineticin-1 (PROK1) and prokineticin-2 (PROK2), and their cognate G protein-coupled receptors. The prokineticins were originally identified as endogenous regulators of gastrointestinal motility. Currently, these bioactive peptides are involved in a wide spectrum of biological functions, including angiogenesis, neurogenesis, circadian rhythms, nociception, hematopoiesis and immune response. Mice homozygous for null mutations in <i>Prokr2 </i>or <i>Prok2 </i>recapitulate the human phenotype of Kallmann syndrome, exhibiting severe atrophy of the reproductive system and hypoplastic olfactory bulbs. Indeed, the evidence from several naturally inactivating mutations in the <i>PROK2</i> and <i>PROKR2</i> genes in patients with Kallmann syndrome and normosmic hypogonadotropic hypogonadism also indicate the essential role of PROK2 in olfactory bulb morphogenesis and GnRH secretion in humans." @default.
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• W1966048528 date "2010-01-01" @default.
• W1966048528 modified "2023-10-18" @default.
• W1966048528 title "The Role of Prokineticins in the Pathogenesis of Hypogonadotropic Hypogonadism" @default.
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• W1966048528 doi "https://doi.org/10.1159/000308880" @default.
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