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- W1966049109 abstract "Unlike antibodies against beta-amyloid, little is known about serum antibodies to neuron- and disease-specific cytoskeletal proteins in patients with Alzheimer disease (AD). Moreover, fluctuations of these antibodies over time are not known, neither. Antibodies against three targets (tau, light (NFL) and heavy (NFH) neurofilaments) were measured using ELISA in 100 serum samples from 51 cognitively normal elderly controls (NC) and 49 patients with AD fulfilling NINCDS-ADRDA criteria. We also measured all three anti-neurocytoskeletal antibodies in paired serum samples from 48 NC and 11 AD patients after 562 ± 161 days in NC and after 441 ± 253 days in AD. The AD patients had significantly lower levels of anti-tau antibodies (P = 0.03) and more anti-NFH antibodies (p = 0.005) than those in the control group at baseline. On the contrary, anti-NFL antibodies or total IgG concentrations in serum did not differ. All three antibodies remained stable in both groups except for a selective and significant anti-tau decline in AD patients (P = 0.03). The different responses to these antigens suggest some antibody selectivity in AD. The significant decline was observed for only serum anti-tau antibodies in AD patients over time and it corresponds to lower levels in these patients. Our findings indicate a novel and special feature of disease-relevant antigens and humoral autoimmunity in AD." @default.
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- W1966049109 date "2012-07-01" @default.
- W1966049109 modified "2023-09-27" @default.
- W1966049109 title "P2-050: Lower serum antibodies against tau protein and heavy neurofilament in Alzheimer's disease" @default.
- W1966049109 doi "https://doi.org/10.1016/j.jalz.2012.05.2144" @default.
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