FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966049316> ?p ?o ?g. }

• W1966049316 endingPage "3704" @default.
• W1966049316 startingPage "3698" @default.
• W1966049316 abstract "Bulk physicochemical properties of bovine plasma fibrinogen (Fb) in electrolyte solutions were characterized. These comprised determination of the diffusion coefficient (hydrodynamic radius), electrophoretic mobility, and isoelectric point (iep). The hydrodynamic radius of Fb for the ionic strength of 0.15 M was 12.7 nm for pH 7.4 (physiological conditions) and 12 nm for pH 9.5. Using these values, the number of uncompensated (electrokinetic) charges on the protein Nc was calculated from the electrophoretic mobility data. It was found that for physiological condition (pH 7.4, I = 0.15), Nc = −7.6. For pH 9.5 and I = 10−2, Nc = −26. On the other hand, Nc became zero independent of the ionic strength at pH 5.8, which was identified as the iep. Consequently, for pH <5.8, Nc attained positive values, approaching 26 for lower ionic strength and pH 3.5. It was also found from the hydrodynamic diameter measurements that for a pH range close to the iep, that is, 4−7, the stability of Fb suspension was very low. These physicochemical characteristics were supplemented by dynamic viscosity measurements, carried out as a function of Fb bulk volume concentration, for various pH values. Using these experimental data the contour length of 80 nm was predicted for Fb molecules in electrolyte solutions. On the other hand, the effective length of the molecule was 53−55 nm for physiological conditions, which suggested a collapsed state of the terminal chains. However, for the range of pH outside the iep, its effective length increased to 65−68 nm. This was interpreted in terms of a significant unfolding of the terminal chains of Fb caused by electrostatic repulsion. The effective charge, contour length, and effective length data derived in this work seem to be the first of this type reported in the literature." @default.
• W1966049316 created "2016-06-24" @default.
• W1966049316 creator A5028179115 @default.
• W1966049316 creator A5046279559 @default.
• W1966049316 creator A5079834367 @default.
• W1966049316 date "2009-02-19" @default.
• W1966049316 modified "2023-10-12" @default.
• W1966049316 title "Structure of Fibrinogen in Electrolyte Solutions Derived from Dynamic Light Scattering (DLS) and Viscosity Measurements" @default.
• W1966049316 cites W1907444416 @default.
• W1966049316 cites W1971378635 @default.
• W1966049316 cites W1976366973 @default.
• W1966049316 cites W1979219785 @default.
• W1966049316 cites W1980514501 @default.
• W1966049316 cites W1985859364 @default.
• W1966049316 cites W1988585128 @default.
• W1966049316 cites W1994342473 @default.
• W1966049316 cites W1995176621 @default.
• W1966049316 cites W1998047527 @default.
• W1966049316 cites W1998368428 @default.
• W1966049316 cites W2001106116 @default.
• W1966049316 cites W2002435133 @default.
• W1966049316 cites W2004472259 @default.
• W1966049316 cites W2010417886 @default.
• W1966049316 cites W2012646915 @default.
• W1966049316 cites W2012968377 @default.
• W1966049316 cites W2013707087 @default.
• W1966049316 cites W2016597149 @default.
• W1966049316 cites W2018136550 @default.
• W1966049316 cites W2019888372 @default.
• W1966049316 cites W2022212201 @default.
• W1966049316 cites W2023960215 @default.
• W1966049316 cites W2025561491 @default.
• W1966049316 cites W2032913207 @default.
• W1966049316 cites W2033484281 @default.
• W1966049316 cites W2043989872 @default.
• W1966049316 cites W2051361096 @default.
• W1966049316 cites W2052113550 @default.
• W1966049316 cites W2053159898 @default.
• W1966049316 cites W2067230558 @default.
• W1966049316 cites W2067601493 @default.
• W1966049316 cites W2068427632 @default.
• W1966049316 cites W2077019855 @default.
• W1966049316 cites W2087293539 @default.
• W1966049316 cites W2090980024 @default.
• W1966049316 cites W2097517504 @default.
• W1966049316 cites W2157898316 @default.
• W1966049316 cites W2160124075 @default.
• W1966049316 cites W31976002 @default.
• W1966049316 cites W4324262994 @default.
• W1966049316 cites W4376453207 @default.
• W1966049316 cites W636025489 @default.
• W1966049316 doi "https://doi.org/10.1021/la803662a" @default.
• W1966049316 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/19228031" @default.
• W1966049316 hasPublicationYear "2009" @default.
• W1966049316 type Work @default.
• W1966049316 sameAs 1966049316 @default.
• W1966049316 citedByCount "95" @default.
• W1966049316 countsByYear W19660493162012 @default.
• W1966049316 countsByYear W19660493162013 @default.
• W1966049316 countsByYear W19660493162014 @default.
• W1966049316 countsByYear W19660493162015 @default.
• W1966049316 countsByYear W19660493162016 @default.
• W1966049316 countsByYear W19660493162017 @default.
• W1966049316 countsByYear W19660493162018 @default.
• W1966049316 countsByYear W19660493162019 @default.
• W1966049316 countsByYear W19660493162020 @default.
• W1966049316 countsByYear W19660493162021 @default.
• W1966049316 countsByYear W19660493162022 @default.
• W1966049316 countsByYear W19660493162023 @default.
• W1966049316 crossrefType "journal-article" @default.
• W1966049316 hasAuthorship W1966049316A5028179115 @default.
• W1966049316 hasAuthorship W1966049316A5046279559 @default.
• W1966049316 hasAuthorship W1966049316A5079834367 @default.
• W1966049316 hasConcept C11268172 @default.
• W1966049316 hasConcept C113196181 @default.
• W1966049316 hasConcept C121332964 @default.
• W1966049316 hasConcept C127172972 @default.
• W1966049316 hasConcept C14631669 @default.
• W1966049316 hasConcept C147789679 @default.
• W1966049316 hasConcept C155672457 @default.
• W1966049316 hasConcept C171250308 @default.
• W1966049316 hasConcept C17525397 @default.
• W1966049316 hasConcept C178790620 @default.
• W1966049316 hasConcept C181199279 @default.
• W1966049316 hasConcept C184651966 @default.
• W1966049316 hasConcept C185592680 @default.
• W1966049316 hasConcept C187428577 @default.
• W1966049316 hasConcept C192562407 @default.
• W1966049316 hasConcept C207374878 @default.
• W1966049316 hasConcept C26360006 @default.
• W1966049316 hasConcept C27703432 @default.
• W1966049316 hasConcept C40250595 @default.
• W1966049316 hasConcept C43617362 @default.
• W1966049316 hasConcept C521977710 @default.
• W1966049316 hasConcept C55493867 @default.
• W1966049316 hasConcept C68801617 @default.
• W1966049316 hasConcept C69357855 @default.
• W1966049316 hasConcept C96294017 @default.

• next