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- W1966049888 abstract "This study assessed the effects of partial reductions in exercise work load on radionuclide angiographic indexes of ischemia in patients with coronary artery disease. Left ventricular function was measured by first pass radionuclide angiography in 43 male patients at rest, during an ischemic response to symptom-limited exercise and immediately after a partial reduction in work load. To assess the sensitivity of exercise-induced left ventricular dysfunction to reductions in work load, the effects of moderate (50%; Group 1) and small (200 kilopond-meters/min; Group 2) reductions in work load were analyzed. In Group 1, ejection fraction decreased from 49 ± 18% (mean ± standard deviation) at rest to 43 ± 16% at symptom-limited exercise, and then increased to 52 ±21% during work load reduction (p < 0.001). In Group 2, ejection fraction decreased from 53 ± 18% at rest to 44 ± 16% at symptom-limited exercise, and then increased to 52 ± 19% during work load reduction (p < 0.001). If the ejection fraction response during work load reduction rather than during symptom-limited exercise was considered for diagnostic purposes, the sensitivity would have been reduced from 100 to 52% in Group 1 and to 70% in Group 2. The ejection fraction increased during work load reduction despite persistent ST segment depression in eight patients in Group 1 and in nine patients in Group 2. Increases in ejection fraction during work load reduction were associated with increases in the ratio of systolic blood pressure to end-systolic volume and lessening of regional wall motion abnormalities. In patients who develop ischemia during symptom-limited exercise, small decreases in work load which are accompanied by minor hemodynamic changes may result in a rebound increase in left ventricular function and significant reduction in the diagnostic sensitivity of the exercise radionuclide angiogram." @default.
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- W1966049888 date "1983-09-01" @default.
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- W1966049888 title "Effect of partial decreases in exercise work load on radionuclide indexes of ischemia" @default.
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- W1966049888 doi "https://doi.org/10.1016/s0735-1097(83)80280-0" @default.
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