Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966061444> ?p ?o ?g. }
Showing items 1 to 78 of
78
with 100 items per page.
- W1966061444 endingPage "181" @default.
- W1966061444 startingPage "174" @default.
- W1966061444 abstract "The amount of surfactant present in the intra-alveolar space is mainly regulated by the synthesis and recycling of surfactant by type II pneumocytes. Biochemical analyses have shown that the surfactant level is frequently diminished and that protein-rich exudate can further interfere with surfactant function in the lungs of adult respiratory distress syndrome (ARDS) patients. The microenvironmental changes that occur in the alveoli of burned patients, who are prone to developing ARDS, are unclear. Therefore, using an in vitro rat lung organotypic culture, we showed that the sera of rats with a 3-day old, third-degree thermal injury (25-30% total body surface area) inhibited surfactant synthesis in organotypically cultured rat lung cells. Surfactant precursor, 3H-choline, incorporation into the surfactant was 58% of control. Using liposomes made of dipalmitoyl phosphatidylcholine and phosphatidylglycerol (8:1, v/v) or surfactant we showed that surfactant endocytosis by purified type II alveolar cells is an active, temperature-dependent process, and correlates with the quantity of surfactant present in the milieu. We also found that plasma protein-rich fluid interfered with surfactant endocytosis by the purified type II pneumocytes. These two processes of inhibition of surfactant synthesis and its reutilization by these cells may contribute to the pathogenesis of ARDS." @default.
- W1966061444 created "2016-06-24" @default.
- W1966061444 creator A5007745003 @default.
- W1966061444 creator A5044793226 @default.
- W1966061444 creator A5051684748 @default.
- W1966061444 creator A5069001170 @default.
- W1966061444 date "1991-02-01" @default.
- W1966061444 modified "2023-09-25" @default.
- W1966061444 title "The Rat Lung Organotypic Culture" @default.
- W1966061444 doi "https://doi.org/10.1097/00005373-199102000-00004" @default.
- W1966061444 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1994076" @default.
- W1966061444 hasPublicationYear "1991" @default.
- W1966061444 type Work @default.
- W1966061444 sameAs 1966061444 @default.
- W1966061444 citedByCount "1" @default.
- W1966061444 crossrefType "journal-article" @default.
- W1966061444 hasAuthorship W1966061444A5007745003 @default.
- W1966061444 hasAuthorship W1966061444A5044793226 @default.
- W1966061444 hasAuthorship W1966061444A5051684748 @default.
- W1966061444 hasAuthorship W1966061444A5069001170 @default.
- W1966061444 hasConcept C126322002 @default.
- W1966061444 hasConcept C1491633281 @default.
- W1966061444 hasConcept C185592680 @default.
- W1966061444 hasConcept C202751555 @default.
- W1966061444 hasConcept C2776330855 @default.
- W1966061444 hasConcept C2776348555 @default.
- W1966061444 hasConcept C2777714996 @default.
- W1966061444 hasConcept C2778543330 @default.
- W1966061444 hasConcept C2778918659 @default.
- W1966061444 hasConcept C2779244956 @default.
- W1966061444 hasConcept C2780726299 @default.
- W1966061444 hasConcept C28005876 @default.
- W1966061444 hasConcept C41625074 @default.
- W1966061444 hasConcept C55493867 @default.
- W1966061444 hasConcept C58226133 @default.
- W1966061444 hasConcept C71924100 @default.
- W1966061444 hasConcept C86803240 @default.
- W1966061444 hasConcept C95444343 @default.
- W1966061444 hasConceptScore W1966061444C126322002 @default.
- W1966061444 hasConceptScore W1966061444C1491633281 @default.
- W1966061444 hasConceptScore W1966061444C185592680 @default.
- W1966061444 hasConceptScore W1966061444C202751555 @default.
- W1966061444 hasConceptScore W1966061444C2776330855 @default.
- W1966061444 hasConceptScore W1966061444C2776348555 @default.
- W1966061444 hasConceptScore W1966061444C2777714996 @default.
- W1966061444 hasConceptScore W1966061444C2778543330 @default.
- W1966061444 hasConceptScore W1966061444C2778918659 @default.
- W1966061444 hasConceptScore W1966061444C2779244956 @default.
- W1966061444 hasConceptScore W1966061444C2780726299 @default.
- W1966061444 hasConceptScore W1966061444C28005876 @default.
- W1966061444 hasConceptScore W1966061444C41625074 @default.
- W1966061444 hasConceptScore W1966061444C55493867 @default.
- W1966061444 hasConceptScore W1966061444C58226133 @default.
- W1966061444 hasConceptScore W1966061444C71924100 @default.
- W1966061444 hasConceptScore W1966061444C86803240 @default.
- W1966061444 hasConceptScore W1966061444C95444343 @default.
- W1966061444 hasIssue "2" @default.
- W1966061444 hasLocation W19660614441 @default.
- W1966061444 hasLocation W19660614442 @default.
- W1966061444 hasOpenAccess W1966061444 @default.
- W1966061444 hasPrimaryLocation W19660614441 @default.
- W1966061444 hasRelatedWork W1966061444 @default.
- W1966061444 hasRelatedWork W2032169846 @default.
- W1966061444 hasRelatedWork W2054489835 @default.
- W1966061444 hasRelatedWork W2070364452 @default.
- W1966061444 hasRelatedWork W2074036726 @default.
- W1966061444 hasRelatedWork W2089155826 @default.
- W1966061444 hasRelatedWork W2102825524 @default.
- W1966061444 hasRelatedWork W2279447807 @default.
- W1966061444 hasRelatedWork W4238556147 @default.
- W1966061444 hasRelatedWork W2527658325 @default.
- W1966061444 hasVolume "31" @default.
- W1966061444 isParatext "false" @default.
- W1966061444 isRetracted "false" @default.
- W1966061444 magId "1966061444" @default.
- W1966061444 workType "article" @default.