FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966062493> ?p ?o ?g. }

• W1966062493 endingPage "e63588" @default.
• W1966062493 startingPage "e63588" @default.
• W1966062493 abstract "Interleukin-26 (IL-26) is one of the cytokines secreted by Th17 cells whose role in human tumors remains unknown. Here, we investigated the expression and potential role of IL-26 in human gastric cancer (GC). The expression of IL-26 and related molecules such as IL-20R1, STAT1 and STAT3 was examined by real-time PCR and immunohistochemisty. The effects of IL-26 on cell proliferation and cisplatin-induced apoptosis were analyzed by BrdU cooperation assay and PI-Annexin V co-staining, respectively. Lentiviral mediated siRNA was used to explore its mechanism of action, and IL-26 related signaling was analyzed by western blotting. Human GC tissues showed increased levels of IL-26 and its related molecules and activation of STAT3 signaling, whereas STAT1 activation did not differ significantly between GC and normal gastric tissues. Moreover, IL-26 was primarily produced by Th17 and NK cells. IL-26 promoted the proliferation and survival of MKN45 and SGC-7901 gastric cancer cells in a dose-dependent manner. Furthermore, IL-20R2 and IL-10R1, which are two essential receptors for IL-26 signaling, were expressed in both cell lines. IL-26 activated STAT1 and STAT3 signaling; however, the upregulation of the expression of Bcl-2, Bcl-xl and c-myc indicated that the effect of IL-26 is mediated by STAT3 activation. Knockdown of STAT1 and STAT3 expression suggested that the proliferative and anti-apoptotic effects of IL-26 are mediated by the modulation of STAT1/STAT3 activation. In summary, elevated levels of IL-26 in human GC promote proliferation and survival by modulating STAT1/STAT3 signaling." @default.
• W1966062493 created "2016-06-24" @default.
• W1966062493 creator A5009667109 @default.
• W1966062493 creator A5014647241 @default.
• W1966062493 creator A5023242949 @default.
• W1966062493 creator A5034257494 @default.
• W1966062493 creator A5053789239 @default.
• W1966062493 creator A5062599910 @default.
• W1966062493 creator A5089610091 @default.
• W1966062493 date "2013-05-21" @default.
• W1966062493 modified "2023-10-16" @default.
• W1966062493 title "IL-26 Promotes the Proliferation and Survival of Human Gastric Cancer Cells by Regulating the Balance of STAT1 and STAT3 Activation" @default.
• W1966062493 cites W1522761582 @default.
• W1966062493 cites W1788079032 @default.
• W1966062493 cites W1965591985 @default.
• W1966062493 cites W1965592851 @default.
• W1966062493 cites W1973454407 @default.
• W1966062493 cites W1979332322 @default.
• W1966062493 cites W1981851073 @default.
• W1966062493 cites W1986120120 @default.
• W1966062493 cites W1991147696 @default.
• W1966062493 cites W2002987322 @default.
• W1966062493 cites W2003651863 @default.
• W1966062493 cites W2004289037 @default.
• W1966062493 cites W2004867568 @default.
• W1966062493 cites W2006711580 @default.
• W1966062493 cites W2007868505 @default.
• W1966062493 cites W2008512592 @default.
• W1966062493 cites W2020229473 @default.
• W1966062493 cites W2022971232 @default.
• W1966062493 cites W2036405181 @default.
• W1966062493 cites W2037638312 @default.
• W1966062493 cites W2040104429 @default.
• W1966062493 cites W2043437568 @default.
• W1966062493 cites W2044227662 @default.
• W1966062493 cites W2048952291 @default.
• W1966062493 cites W2063044697 @default.
• W1966062493 cites W2067981880 @default.
• W1966062493 cites W2070518150 @default.
• W1966062493 cites W2084885786 @default.
• W1966062493 cites W2092289533 @default.
• W1966062493 cites W2139257870 @default.
• W1966062493 cites W2150903402 @default.
• W1966062493 cites W4253737346 @default.
• W1966062493 doi "https://doi.org/10.1371/journal.pone.0063588" @default.
• W1966062493 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3660585" @default.
• W1966062493 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23704922" @default.
• W1966062493 hasPublicationYear "2013" @default.
• W1966062493 type Work @default.
• W1966062493 sameAs 1966062493 @default.
• W1966062493 citedByCount "55" @default.
• W1966062493 countsByYear W19660624932014 @default.
• W1966062493 countsByYear W19660624932015 @default.
• W1966062493 countsByYear W19660624932016 @default.
• W1966062493 countsByYear W19660624932017 @default.
• W1966062493 countsByYear W19660624932018 @default.
• W1966062493 countsByYear W19660624932019 @default.
• W1966062493 countsByYear W19660624932020 @default.
• W1966062493 countsByYear W19660624932021 @default.
• W1966062493 countsByYear W19660624932022 @default.
• W1966062493 countsByYear W19660624932023 @default.
• W1966062493 crossrefType "journal-article" @default.
• W1966062493 hasAuthorship W1966062493A5009667109 @default.
• W1966062493 hasAuthorship W1966062493A5014647241 @default.
• W1966062493 hasAuthorship W1966062493A5023242949 @default.
• W1966062493 hasAuthorship W1966062493A5034257494 @default.
• W1966062493 hasAuthorship W1966062493A5053789239 @default.
• W1966062493 hasAuthorship W1966062493A5062599910 @default.
• W1966062493 hasAuthorship W1966062493A5089610091 @default.
• W1966062493 hasBestOaLocation W19660624931 @default.
• W1966062493 hasConcept C104317684 @default.
• W1966062493 hasConcept C121608353 @default.
• W1966062493 hasConcept C127561419 @default.
• W1966062493 hasConcept C153911025 @default.
• W1966062493 hasConcept C173396325 @default.
• W1966062493 hasConcept C185592680 @default.
• W1966062493 hasConcept C190283241 @default.
• W1966062493 hasConcept C2777003663 @default.
• W1966062493 hasConcept C2778923194 @default.
• W1966062493 hasConcept C502942594 @default.
• W1966062493 hasConcept C54355233 @default.
• W1966062493 hasConcept C55493867 @default.
• W1966062493 hasConcept C62112901 @default.
• W1966062493 hasConcept C62478195 @default.
• W1966062493 hasConcept C86803240 @default.
• W1966062493 hasConcept C88634738 @default.
• W1966062493 hasConcept C95444343 @default.
• W1966062493 hasConcept C96232424 @default.
• W1966062493 hasConceptScore W1966062493C104317684 @default.
• W1966062493 hasConceptScore W1966062493C121608353 @default.
• W1966062493 hasConceptScore W1966062493C127561419 @default.
• W1966062493 hasConceptScore W1966062493C153911025 @default.
• W1966062493 hasConceptScore W1966062493C173396325 @default.
• W1966062493 hasConceptScore W1966062493C185592680 @default.
• W1966062493 hasConceptScore W1966062493C190283241 @default.
• W1966062493 hasConceptScore W1966062493C2777003663 @default.
• W1966062493 hasConceptScore W1966062493C2778923194 @default.
• W1966062493 hasConceptScore W1966062493C502942594 @default.

• next