Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966062502> ?p ?o ?g. }
- W1966062502 endingPage "1104" @default.
- W1966062502 startingPage "1092" @default.
- W1966062502 abstract "Abstract Genomic alterations play a crucial role in the development and progression of diffuse large B-cell lymphomas (DLBCLs). We determined gene copy number alterations (GCNAs) of TP53, CDKN2A, CDKN1B, BCL2, MYC, REL, and RB1 with a single polymerase chain reaction (PCR) assay (quantitative multiplex PCR of short fragments [QMPSF]) in a cohort of 114 patients with DLBCL to assess their prognostic value and relationship with the gene expression profile. Losses of TP53 and CDKN2A, observed in 8% and 35% of patients, respectively, were significantly associated with a shorter survival after rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone (R-CHOP) treatment, independently of the International Prognostic Index and of the cell of origin. Analysis of the 9p21 genomic region indicated that transcripts encoding p14ARF and p16INK4A were both disrupted in most patients with CDKN2A deletion. These patients predominantly had an activated B-cell profile and showed a specific gene expression signature, characterized by dysregulation of the RB/E2F pathway, activation of cellular metabolism, and decreased immune and inflammatory responses. These features may constitute the molecular basis sustaining the unfavorable outcome and chemoresistance of this DLBCL subgroup. Detection of TP53 and CDKN2A loss by QMPSF is a powerful tool that could be used for patient stratification in future clinical trials." @default.
- W1966062502 created "2016-06-24" @default.
- W1966062502 creator A5003078312 @default.
- W1966062502 creator A5003105021 @default.
- W1966062502 creator A5013080078 @default.
- W1966062502 creator A5014546710 @default.
- W1966062502 creator A5031041032 @default.
- W1966062502 creator A5033073385 @default.
- W1966062502 creator A5034053189 @default.
- W1966062502 creator A5042627121 @default.
- W1966062502 creator A5051581294 @default.
- W1966062502 creator A5057563040 @default.
- W1966062502 creator A5065987951 @default.
- W1966062502 creator A5082700087 @default.
- W1966062502 creator A5083740971 @default.
- W1966062502 creator A5086354986 @default.
- W1966062502 creator A5086620890 @default.
- W1966062502 creator A5089962133 @default.
- W1966062502 date "2010-08-19" @default.
- W1966062502 modified "2023-10-16" @default.
- W1966062502 title "Diffuse large B-cell lymphomas with CDKN2A deletion have a distinct gene expression signature and a poor prognosis under R-CHOP treatment: a GELA study" @default.
- W1966062502 cites W1966753131 @default.
- W1966062502 cites W1968117566 @default.
- W1966062502 cites W1970150235 @default.
- W1966062502 cites W1976200382 @default.
- W1966062502 cites W1977534321 @default.
- W1966062502 cites W1986281723 @default.
- W1966062502 cites W1990900623 @default.
- W1966062502 cites W1992478145 @default.
- W1966062502 cites W1997765594 @default.
- W1966062502 cites W2003696664 @default.
- W1966062502 cites W2022013393 @default.
- W1966062502 cites W2024354411 @default.
- W1966062502 cites W2026214119 @default.
- W1966062502 cites W2030105242 @default.
- W1966062502 cites W2030788193 @default.
- W1966062502 cites W2034260252 @default.
- W1966062502 cites W2034992259 @default.
- W1966062502 cites W2035135710 @default.
- W1966062502 cites W2036242721 @default.
- W1966062502 cites W2037796411 @default.
- W1966062502 cites W2056188137 @default.
- W1966062502 cites W2068294374 @default.
- W1966062502 cites W2070064901 @default.
- W1966062502 cites W2097655753 @default.
- W1966062502 cites W2097676652 @default.
- W1966062502 cites W2103821553 @default.
- W1966062502 cites W2111163870 @default.
- W1966062502 cites W2121988260 @default.
- W1966062502 cites W2130410032 @default.
- W1966062502 cites W2132749042 @default.
- W1966062502 cites W2132786809 @default.
- W1966062502 cites W2133131759 @default.
- W1966062502 cites W2134736660 @default.
- W1966062502 cites W2139954541 @default.
- W1966062502 cites W2140065103 @default.
- W1966062502 cites W2143752296 @default.
- W1966062502 cites W2147246240 @default.
- W1966062502 cites W2150382709 @default.
- W1966062502 cites W2151638388 @default.
- W1966062502 cites W2160697532 @default.
- W1966062502 cites W2163990748 @default.
- W1966062502 cites W2167571754 @default.
- W1966062502 doi "https://doi.org/10.1182/blood-2009-10-247122" @default.
- W1966062502 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20435884" @default.
- W1966062502 hasPublicationYear "2010" @default.
- W1966062502 type Work @default.
- W1966062502 sameAs 1966062502 @default.
- W1966062502 citedByCount "115" @default.
- W1966062502 countsByYear W19660625022012 @default.
- W1966062502 countsByYear W19660625022013 @default.
- W1966062502 countsByYear W19660625022014 @default.
- W1966062502 countsByYear W19660625022015 @default.
- W1966062502 countsByYear W19660625022016 @default.
- W1966062502 countsByYear W19660625022017 @default.
- W1966062502 countsByYear W19660625022018 @default.
- W1966062502 countsByYear W19660625022019 @default.
- W1966062502 countsByYear W19660625022020 @default.
- W1966062502 countsByYear W19660625022021 @default.
- W1966062502 countsByYear W19660625022022 @default.
- W1966062502 countsByYear W19660625022023 @default.
- W1966062502 crossrefType "journal-article" @default.
- W1966062502 hasAuthorship W1966062502A5003078312 @default.
- W1966062502 hasAuthorship W1966062502A5003105021 @default.
- W1966062502 hasAuthorship W1966062502A5013080078 @default.
- W1966062502 hasAuthorship W1966062502A5014546710 @default.
- W1966062502 hasAuthorship W1966062502A5031041032 @default.
- W1966062502 hasAuthorship W1966062502A5033073385 @default.
- W1966062502 hasAuthorship W1966062502A5034053189 @default.
- W1966062502 hasAuthorship W1966062502A5042627121 @default.
- W1966062502 hasAuthorship W1966062502A5051581294 @default.
- W1966062502 hasAuthorship W1966062502A5057563040 @default.
- W1966062502 hasAuthorship W1966062502A5065987951 @default.
- W1966062502 hasAuthorship W1966062502A5082700087 @default.
- W1966062502 hasAuthorship W1966062502A5083740971 @default.
- W1966062502 hasAuthorship W1966062502A5086354986 @default.
- W1966062502 hasAuthorship W1966062502A5086620890 @default.
- W1966062502 hasAuthorship W1966062502A5089962133 @default.