FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966068789> ?p ?o ?g. }

• W1966068789 endingPage "850" @default.
• W1966068789 startingPage "842" @default.
• W1966068789 abstract "Summary Factor XIII is responsible for the cross-linking of fibrin γ-chains in the early stages of clot formation, whilst α-chain cross-linking occurs at a slower rate. Although γ- and α-chain cross-linking was previously shown to contribute to clot stiffness, the role of cross-linking of both chains in determining clot structure is currently unknown. Therefore, the aim of this study was to determine the role of individual α- and γ-chain cross-linking during clot formation, and its effects on clot structure. We made use of a recombinant fibrinogen (γQ398N/Q399N/K406R), which does not allow for y-chain cross-linking. In the absence of cross-linking, intact D-D interface was shown to play a potential role in fibre appearance time, clot stiffness and elasticity. Cross-linking of the fibrin α-chain played a role in the thickening of the fibrin fibres over time, and decreased lysis rate in the absence of α2-antiplasmin. We also showed that α-chain cross-linking played a role in the timing of fibre appearance, straightening fibres, increasing clot stiffness and reducing clot deformation. Cross-linking of the γ-chain played a role in fibrin fibre appearance time and fibre density. Our results show that α- and γ-chain cross-linking play independent and specific roles in fibrin clot formation and structure." @default.
• W1966068789 created "2016-06-24" @default.
• W1966068789 creator A5006903396 @default.
• W1966068789 creator A5008277035 @default.
• W1966068789 creator A5066400080 @default.
• W1966068789 creator A5078965269 @default.
• W1966068789 creator A5086634691 @default.
• W1966068789 creator A5088742794 @default.
• W1966068789 date "2014-01-01" @default.
• W1966068789 modified "2023-09-23" @default.
• W1966068789 title "Roles of fibrin α- and γ-chain specific cross-linking by FXIIIa in fibrin structure and function" @default.
• W1966068789 cites W1711208506 @default.
• W1966068789 cites W1970063984 @default.
• W1966068789 cites W1971012945 @default.
• W1966068789 cites W1987102104 @default.
• W1966068789 cites W1997614271 @default.
• W1966068789 cites W1998529033 @default.
• W1966068789 cites W2003305047 @default.
• W1966068789 cites W2007801689 @default.
• W1966068789 cites W2015577105 @default.
• W1966068789 cites W2025358191 @default.
• W1966068789 cites W2035998381 @default.
• W1966068789 cites W2037160988 @default.
• W1966068789 cites W2038236709 @default.
• W1966068789 cites W2039675025 @default.
• W1966068789 cites W2043294207 @default.
• W1966068789 cites W2043495219 @default.
• W1966068789 cites W2045529021 @default.
• W1966068789 cites W2045737844 @default.
• W1966068789 cites W2057577566 @default.
• W1966068789 cites W2060792403 @default.
• W1966068789 cites W2078132464 @default.
• W1966068789 cites W2091859469 @default.
• W1966068789 cites W2094517457 @default.
• W1966068789 cites W2120487268 @default.
• W1966068789 cites W2154036638 @default.
• W1966068789 cites W2191994209 @default.
• W1966068789 cites W2253070829 @default.
• W1966068789 cites W77183089 @default.
• W1966068789 doi "https://doi.org/10.1160/th13-10-0855" @default.
• W1966068789 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24430058" @default.
• W1966068789 hasPublicationYear "2014" @default.
• W1966068789 type Work @default.
• W1966068789 sameAs 1966068789 @default.
• W1966068789 citedByCount "64" @default.
• W1966068789 countsByYear W19660687892014 @default.
• W1966068789 countsByYear W19660687892015 @default.
• W1966068789 countsByYear W19660687892016 @default.
• W1966068789 countsByYear W19660687892017 @default.
• W1966068789 countsByYear W19660687892018 @default.
• W1966068789 countsByYear W19660687892019 @default.
• W1966068789 countsByYear W19660687892020 @default.
• W1966068789 countsByYear W19660687892021 @default.
• W1966068789 countsByYear W19660687892022 @default.
• W1966068789 countsByYear W19660687892023 @default.
• W1966068789 crossrefType "journal-article" @default.
• W1966068789 hasAuthorship W1966068789A5006903396 @default.
• W1966068789 hasAuthorship W1966068789A5008277035 @default.
• W1966068789 hasAuthorship W1966068789A5066400080 @default.
• W1966068789 hasAuthorship W1966068789A5078965269 @default.
• W1966068789 hasAuthorship W1966068789A5086634691 @default.
• W1966068789 hasAuthorship W1966068789A5088742794 @default.
• W1966068789 hasBestOaLocation W19660687892 @default.
• W1966068789 hasConcept C12554922 @default.
• W1966068789 hasConcept C185592680 @default.
• W1966068789 hasConcept C203014093 @default.
• W1966068789 hasConcept C2779036427 @default.
• W1966068789 hasConcept C2911038020 @default.
• W1966068789 hasConcept C54173615 @default.
• W1966068789 hasConcept C55493867 @default.
• W1966068789 hasConcept C71924100 @default.
• W1966068789 hasConcept C86803240 @default.
• W1966068789 hasConceptScore W1966068789C12554922 @default.
• W1966068789 hasConceptScore W1966068789C185592680 @default.
• W1966068789 hasConceptScore W1966068789C203014093 @default.
• W1966068789 hasConceptScore W1966068789C2779036427 @default.
• W1966068789 hasConceptScore W1966068789C2911038020 @default.
• W1966068789 hasConceptScore W1966068789C54173615 @default.
• W1966068789 hasConceptScore W1966068789C55493867 @default.
• W1966068789 hasConceptScore W1966068789C71924100 @default.
• W1966068789 hasConceptScore W1966068789C86803240 @default.
• W1966068789 hasFunder F4320319992 @default.
• W1966068789 hasIssue "05" @default.
• W1966068789 hasLocation W19660687891 @default.
• W1966068789 hasLocation W19660687892 @default.
• W1966068789 hasLocation W19660687893 @default.
• W1966068789 hasOpenAccess W1966068789 @default.
• W1966068789 hasPrimaryLocation W19660687891 @default.
• W1966068789 hasRelatedWork W1146534089 @default.
• W1966068789 hasRelatedWork W1711208506 @default.
• W1966068789 hasRelatedWork W1856146912 @default.
• W1966068789 hasRelatedWork W1976268192 @default.
• W1966068789 hasRelatedWork W2037002838 @default.
• W1966068789 hasRelatedWork W2037068857 @default.
• W1966068789 hasRelatedWork W2062949495 @default.
• W1966068789 hasRelatedWork W2065468868 @default.
• W1966068789 hasRelatedWork W2066217822 @default.
• W1966068789 hasRelatedWork W264646983 @default.

• next