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• W1966069043 abstract "Synaptic rules that may determine the interaction between coexisting forms of long-term potentiation (LTP) at glutamatergic central synapses remain unknown. Here, we show that two mechanistically distinct forms of LTP could be induced in thalamic input to the lateral nucleus of the amygdala (LA) with an identical presynaptic stimulation protocol, depending on the level of postsynaptic membrane polarization. One form of LTP, resulting from pairing of postsynaptic depolarization and low-frequency presynaptic stimulation, was both induced and expressed postsynaptically (post-LTP). The same stimulation in the absence of postsynaptic depolarization led to LTP, which was induced and expressed presynaptically (pre-LTP). The inducibility of coexisting pre- and postsynaptic forms of LTP at synapses in thalamic input followed a well-defined hierarchical order, such that pre-LTP was suppressed when post-LTP was induced. This interaction was mediated by activation of cannabinoid type 1 receptors by endogenous cannabinoids released in the lateral nucleus of the amygdala in response to activation of the type 1 metabotropic glutamate receptor. These results suggest a previously unknown mechanism by which the hierarchy of coexisting forms of long-term synaptic plasticity in the neural circuits of learned fear could be established, possibly reflecting the hierarchy of memories for the previously experienced fearful events according to their aversiveness level." @default.
• W1966069043 created "2016-06-24" @default.
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• W1966069043 date "2010-10-18" @default.
• W1966069043 modified "2023-10-14" @default.
• W1966069043 title "Hierarchical order of coexisting pre- and postsynaptic forms of long-term potentiation at synapses in amygdala" @default.
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• W1966069043 doi "https://doi.org/10.1073/pnas.1009803107" @default.
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