FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966071946> ?p ?o ?g. }

• W1966071946 endingPage "1076" @default.
• W1966071946 startingPage "1066" @default.
• W1966071946 abstract "Silymarin inhibits UVB-induced immunosuppression in mouse skin. To identify the molecular mechanisms underlying this effect, we used an adoptive transfer approach in which dendritic cells (DCs) from the draining lymph nodes of donor mice that had been UVB-exposed and sensitized to 2,4,-dinitrofluorobenzene (DNFB) were transferred into naïve recipient mice. The contact hypersensitivity (CHS) response of the recipient mice to DNFB was then measured. When DCs were obtained from UVB-exposed donor mice that were not treated with silymarin, the CHS response was suppressed confirming the role of DCs in the UVB-induced immunosuppression. Silymarin treatment of UVB-exposed donor mice relieved this suppression of the CHS response in the recipients. Silymarin treatment was associated with rapid repair of UVB-induced cyclobutane pyrimidine dimers (CPDs) in DCs and silymarin treatment did not prevent UV-induced immunosuppression in XPA-deficient mice which are unable to repair UV-induced DNA damage. The CHS response in mice receiving DCs from silymarin-treated UV-exposed donor mice also was associated with enhanced secretion of Th1-type cytokines and stimulation of T cells. Adoptive transfer of T cells revealed that transfer of either CD8+ or CD4+ cells from silymarin-treated, UVB-exposed donors resulted in enhancement of the CHS response. Cell culture study showed enhanced secretion of IL-2 and IFNγ by CD8+ T cells, and reduced secretion of Th2 cytokines by CD4+ T cells, obtained from silymarin-treated UVB-exposed mice. These data suggest that DNA repair-dependent functional activation of DCs, a reduction in CD4+ regulatory T-cell activity, and stimulation of CD8+ effector T cells contribute to silymarin-mediated inhibition of UVB-induced immunosuppression." @default.
• W1966071946 created "2016-06-24" @default.
• W1966071946 creator A5036743590 @default.
• W1966071946 creator A5051982352 @default.
• W1966071946 creator A5055174666 @default.
• W1966071946 creator A5058833186 @default.
• W1966071946 creator A5068528854 @default.
• W1966071946 creator A5090998388 @default.
• W1966071946 date "2013-04-01" @default.
• W1966071946 modified "2023-10-03" @default.
• W1966071946 title "Silymarin inhibits ultraviolet radiation-induced immune suppression through DNA repair-dependent activation of dendritic cells and stimulation of effector T cells" @default.
• W1966071946 cites W1483194800 @default.
• W1966071946 cites W1590561990 @default.
• W1966071946 cites W1605861898 @default.
• W1966071946 cites W1731109034 @default.
• W1966071946 cites W1904411247 @default.
• W1966071946 cites W1994330882 @default.
• W1966071946 cites W1998267570 @default.
• W1966071946 cites W2023486746 @default.
• W1966071946 cites W2025910569 @default.
• W1966071946 cites W2038516131 @default.
• W1966071946 cites W2054678965 @default.
• W1966071946 cites W2059926576 @default.
• W1966071946 cites W2061928454 @default.
• W1966071946 cites W2066756933 @default.
• W1966071946 cites W2072059088 @default.
• W1966071946 cites W2072455468 @default.
• W1966071946 cites W2081291884 @default.
• W1966071946 cites W2081555505 @default.
• W1966071946 cites W2084021617 @default.
• W1966071946 cites W2089958864 @default.
• W1966071946 cites W2090957692 @default.
• W1966071946 cites W2102849372 @default.
• W1966071946 cites W2118671268 @default.
• W1966071946 cites W2127735574 @default.
• W1966071946 cites W2129322904 @default.
• W1966071946 cites W2129806196 @default.
• W1966071946 cites W2133513836 @default.
• W1966071946 cites W2138269815 @default.
• W1966071946 cites W2138413317 @default.
• W1966071946 cites W2144111899 @default.
• W1966071946 cites W2146862931 @default.
• W1966071946 cites W2162970323 @default.
• W1966071946 cites W2164506312 @default.
• W1966071946 cites W2167036096 @default.
• W1966071946 cites W2167606285 @default.
• W1966071946 doi "https://doi.org/10.1016/j.bcp.2013.01.026" @default.
• W1966071946 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3604166" @default.
• W1966071946 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23395695" @default.
• W1966071946 hasPublicationYear "2013" @default.
• W1966071946 type Work @default.
• W1966071946 sameAs 1966071946 @default.
• W1966071946 citedByCount "18" @default.
• W1966071946 countsByYear W19660719462013 @default.
• W1966071946 countsByYear W19660719462014 @default.
• W1966071946 countsByYear W19660719462015 @default.
• W1966071946 countsByYear W19660719462017 @default.
• W1966071946 countsByYear W19660719462018 @default.
• W1966071946 countsByYear W19660719462019 @default.
• W1966071946 countsByYear W19660719462020 @default.
• W1966071946 countsByYear W19660719462021 @default.
• W1966071946 countsByYear W19660719462022 @default.
• W1966071946 crossrefType "journal-article" @default.
• W1966071946 hasAuthorship W1966071946A5036743590 @default.
• W1966071946 hasAuthorship W1966071946A5051982352 @default.
• W1966071946 hasAuthorship W1966071946A5055174666 @default.
• W1966071946 hasAuthorship W1966071946A5058833186 @default.
• W1966071946 hasAuthorship W1966071946A5068528854 @default.
• W1966071946 hasAuthorship W1966071946A5090998388 @default.
• W1966071946 hasBestOaLocation W19660719462 @default.
• W1966071946 hasConcept C143425029 @default.
• W1966071946 hasConcept C164027704 @default.
• W1966071946 hasConcept C167672396 @default.
• W1966071946 hasConcept C167975912 @default.
• W1966071946 hasConcept C185592680 @default.
• W1966071946 hasConcept C203014093 @default.
• W1966071946 hasConcept C2776090121 @default.
• W1966071946 hasConcept C2776914184 @default.
• W1966071946 hasConcept C2780252810 @default.
• W1966071946 hasConcept C49039625 @default.
• W1966071946 hasConcept C502942594 @default.
• W1966071946 hasConcept C552990157 @default.
• W1966071946 hasConcept C55493867 @default.
• W1966071946 hasConcept C86803240 @default.
• W1966071946 hasConcept C8891405 @default.
• W1966071946 hasConcept C90375314 @default.
• W1966071946 hasConceptScore W1966071946C143425029 @default.
• W1966071946 hasConceptScore W1966071946C164027704 @default.
• W1966071946 hasConceptScore W1966071946C167672396 @default.
• W1966071946 hasConceptScore W1966071946C167975912 @default.
• W1966071946 hasConceptScore W1966071946C185592680 @default.
• W1966071946 hasConceptScore W1966071946C203014093 @default.
• W1966071946 hasConceptScore W1966071946C2776090121 @default.
• W1966071946 hasConceptScore W1966071946C2776914184 @default.
• W1966071946 hasConceptScore W1966071946C2780252810 @default.
• W1966071946 hasConceptScore W1966071946C49039625 @default.
• W1966071946 hasConceptScore W1966071946C502942594 @default.
• W1966071946 hasConceptScore W1966071946C552990157 @default.

• next