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• W1966072016 abstract "The pathological-basis of late onset dementia is typically conceptualised in terms of cortical amyloid, tau and vascular pathologies. The significance of less common pathologies associated with rare dementias such as Pick bodies, cortical atrophy and sub cortical tau to dementia in the old is unknown. The independent contributions of neuropathologies generally accepted to be common in dementia such as Hirano bodies, gliosis, granulovacuolar degeneration (GVD) are also unknown. The current study investigated the relationship between these less common and ‘disregarded’ neuropathologies to late onset dementia in a population-based sample of older people. The sample was drawn from the Epidemiological CLInicoPathological Studies in Europe (EClipSE) project (www.eclipsestudy.eu) which is a harmonisation of population-based autopsy and clinical data. There were 627 individuals aged 71-103 years, 55% clinically demented at death. Pathologies assessed included: Pick bodies, severe neuronal loss, gliosis and GVD in the cortex and/or hippocampus, as well as brainstem plaques, tangles, severe neuronal loss, gliosis, pigmentary incontinence and Lewy bodies. Associations between each pathological marker and clinical dementia were assessed, taking into account cortical plaques and tangles. All neuropathologies were associated with clinical dementia when controlling for cortical plaques and tangles except Hirano bodies, GVD and brainstem plaques. These included: hippocampal and entorhinal gliosis; cortical, hippocampal and entorhinal neuronal loss, along with brainstem neuronal loss, gliosis, pigmentary incontinence, Lewy bodies and tangles. Pick bodies were present in five individuals, all had clinical dementia. Findings contribute to the emerging understanding that late onset dementia is associated with a broad range of neuropathologies and anatomical regions. Results also illustrate that less common pathologies associated with rare dementia syndromes are seen in the old. The population-based approach gives extra weight to results, as individuals were sourced from, and the sample is representative of, the general population rather than clinics or brain banks. Future work should include these less common and ‘disregarded’ pathologies, particularly within the brainstem, where pathologies were consistently associated with clinical dementia." @default.
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• W1966072016 date "2011-07-01" @default.
• W1966072016 modified "2023-09-27" @default.
• W1966072016 title "P3-282: Less common and “disregarded” pathologies in late onset dementia: what are we missing?" @default.
• W1966072016 doi "https://doi.org/10.1016/j.jalz.2011.05.1724" @default.
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