FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966073555> ?p ?o ?g. }

• W1966073555 endingPage "136" @default.
• W1966073555 startingPage "127" @default.
• W1966073555 abstract "Cell spreading and motility require the extension of the plasma membrane in association with the assembly of actin. In vitro, extension must overcome resistance from tension within the plasma membrane. We report here that the addition of either amphiphilic compounds or fluorescent lipids that expanded the plasma membrane increased the rate of cell spreading and lamellipodial extension, stimulated new lamellipodial extensions, and caused a decrease in the apparent membrane tension. Further, in PDGF-stimulated motility, the increase in the lamellipodial extension rate was associated with a decrease in the apparent membrane tension and decreased membrane-cytoskeleton adhesion through phosphatidylinositol diphosphate hydrolysis. Conversely, when membrane tension was increased by osmotically swelling cells, the extension rate decreased. Therefore, we suggest that the lamellipodial extension process can be activated by a physical signal (perhaps secondarily), and the rate of extension is directly dependent upon the tension in the plasma membrane. Quantitative analysis shows that the lamellipodial extension rate is inversely correlated with the apparent membrane tension. These studies describe a physical chemical mechanism involving changes in membrane-cytoskeleton adhesion through phosphatidylinositol 4,5-biphosphate-protein interactions for modulating and stimulating the biochemical processes that power lamellipodial extension." @default.
• W1966073555 created "2016-06-24" @default.
• W1966073555 creator A5040193425 @default.
• W1966073555 creator A5073630613 @default.
• W1966073555 date "2000-01-10" @default.
• W1966073555 modified "2023-10-12" @default.
• W1966073555 title "Cell Spreading and Lamellipodial Extension Rate Is Regulated by Membrane Tension" @default.
• W1966073555 cites W133332340 @default.
• W1966073555 cites W1512175240 @default.
• W1966073555 cites W1517558040 @default.
• W1966073555 cites W1761198925 @default.
• W1966073555 cites W1963827447 @default.
• W1966073555 cites W1963969404 @default.
• W1966073555 cites W1977197594 @default.
• W1966073555 cites W1991272752 @default.
• W1966073555 cites W1992425845 @default.
• W1966073555 cites W1994351754 @default.
• W1966073555 cites W2012418743 @default.
• W1966073555 cites W2012518316 @default.
• W1966073555 cites W2016271900 @default.
• W1966073555 cites W2017565760 @default.
• W1966073555 cites W2025974183 @default.
• W1966073555 cites W2029115004 @default.
• W1966073555 cites W2030463167 @default.
• W1966073555 cites W2036145275 @default.
• W1966073555 cites W2036745732 @default.
• W1966073555 cites W2045923054 @default.
• W1966073555 cites W2049549946 @default.
• W1966073555 cites W2052378979 @default.
• W1966073555 cites W2054805783 @default.
• W1966073555 cites W2055054035 @default.
• W1966073555 cites W2058658678 @default.
• W1966073555 cites W2059428912 @default.
• W1966073555 cites W2060043235 @default.
• W1966073555 cites W2066665678 @default.
• W1966073555 cites W2079175432 @default.
• W1966073555 cites W2084011431 @default.
• W1966073555 cites W2085725615 @default.
• W1966073555 cites W2087133021 @default.
• W1966073555 cites W2104757164 @default.
• W1966073555 cites W2105416994 @default.
• W1966073555 cites W2121712357 @default.
• W1966073555 cites W2122782850 @default.
• W1966073555 cites W2128407839 @default.
• W1966073555 cites W2157815908 @default.
• W1966073555 cites W2160912589 @default.
• W1966073555 cites W2165748821 @default.
• W1966073555 cites W2166958025 @default.
• W1966073555 cites W2271112592 @default.
• W1966073555 cites W2422015602 @default.
• W1966073555 doi "https://doi.org/10.1083/jcb.148.1.127" @default.
• W1966073555 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2156205" @default.
• W1966073555 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10629223" @default.
• W1966073555 hasPublicationYear "2000" @default.
• W1966073555 type Work @default.
• W1966073555 sameAs 1966073555 @default.
• W1966073555 citedByCount "417" @default.
• W1966073555 countsByYear W19660735552012 @default.
• W1966073555 countsByYear W19660735552013 @default.
• W1966073555 countsByYear W19660735552014 @default.
• W1966073555 countsByYear W19660735552015 @default.
• W1966073555 countsByYear W19660735552016 @default.
• W1966073555 countsByYear W19660735552017 @default.
• W1966073555 countsByYear W19660735552018 @default.
• W1966073555 countsByYear W19660735552019 @default.
• W1966073555 countsByYear W19660735552020 @default.
• W1966073555 countsByYear W19660735552021 @default.
• W1966073555 countsByYear W19660735552022 @default.
• W1966073555 countsByYear W19660735552023 @default.
• W1966073555 crossrefType "journal-article" @default.
• W1966073555 hasAuthorship W1966073555A5040193425 @default.
• W1966073555 hasAuthorship W1966073555A5073630613 @default.
• W1966073555 hasBestOaLocation W19660735551 @default.
• W1966073555 hasConcept C12554922 @default.
• W1966073555 hasConcept C125705527 @default.
• W1966073555 hasConcept C142669718 @default.
• W1966073555 hasConcept C1491633281 @default.
• W1966073555 hasConcept C199528912 @default.
• W1966073555 hasConcept C2778106830 @default.
• W1966073555 hasConcept C2780610907 @default.
• W1966073555 hasConcept C41625074 @default.
• W1966073555 hasConcept C55493867 @default.
• W1966073555 hasConcept C58207958 @default.
• W1966073555 hasConcept C62478195 @default.
• W1966073555 hasConcept C86803240 @default.
• W1966073555 hasConcept C95444343 @default.
• W1966073555 hasConceptScore W1966073555C12554922 @default.
• W1966073555 hasConceptScore W1966073555C125705527 @default.
• W1966073555 hasConceptScore W1966073555C142669718 @default.
• W1966073555 hasConceptScore W1966073555C1491633281 @default.
• W1966073555 hasConceptScore W1966073555C199528912 @default.
• W1966073555 hasConceptScore W1966073555C2778106830 @default.
• W1966073555 hasConceptScore W1966073555C2780610907 @default.
• W1966073555 hasConceptScore W1966073555C41625074 @default.
• W1966073555 hasConceptScore W1966073555C55493867 @default.
• W1966073555 hasConceptScore W1966073555C58207958 @default.
• W1966073555 hasConceptScore W1966073555C62478195 @default.
• W1966073555 hasConceptScore W1966073555C86803240 @default.

• next