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- W1966078408 abstract "Sensory responses of the brain are known to be highly variable, but the origin and functional relevance of this variability have long remained enigmatic. Using the variable foreperiod of a visual discrimination task to assess variability in the primate cerebral cortex, we report that visual evoked response variability is not only tied to variability in ongoing cortical activity, but also predicts mean response time. We used cortical local field potentials, simultaneously recorded from widespread cortical areas, to gauge both ongoing and visually evoked activity. Trial-to-trial variability of sensory evoked responses was strongly modulated by foreperiod duration and correlated both with the cortical variability before stimulus onset as well as with response times. In a separate set of experiments we probed the relation between small saccadic eye movements, foreperiod duration and manual response times. The rate of eye movements was modulated by foreperiod duration and eye position variability was positively correlated with response times. Our results indicate that when the time of a sensory stimulus is predictable, reduction in cortical variability before the stimulus can improve normal behavioral function that depends on the stimulus." @default.
- W1966078408 created "2016-06-24" @default.
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- W1966078408 date "2012-08-24" @default.
- W1966078408 modified "2023-10-18" @default.
- W1966078408 title "Reduced Variability of Ongoing and Evoked Cortical Activity Leads to Improved Behavioral Performance" @default.
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- W1966078408 doi "https://doi.org/10.1371/journal.pone.0043166" @default.
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