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- W1966080396 abstract "(3H)-Quinuclidinyl benzilate (QNB) binding was examined in the cortex, striatum and hippocampus of rats repeatedly exposed to the anticholinesterase, diisopropyl fluorophosphate (DFP). Compared to vehicle-treated controls, a reduction in maximal binding of 25–30% was observed in these brain regions. The reduction in binding was associated with regional acetylcholinesterase (AChE) inhibition of 80–90%. A tendency of lower muscarinic acetylcholine receptor (m-AChR) affinity for (3H)-QNB in control preparations, compared to those from DFP-treated rats, was observed. However, only in the case of the striatal control homogenate was there a significant increase in apparent KD. A concomitant feature of chronically low AChE activity is therefore a reduction, mainly in number, of m-AChR's. These findings support the hypothesis that in the central nervous system (CNS) DFP tolerance and cholinomimetic subsensitivity may involve the m-AChR." @default.
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- W1966080396 date "1979-03-26" @default.
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- W1966080396 title "Reduced binding of (3H)-Quinuclidinyl benzilate associated with chronically low acetylcholinesterase activity" @default.
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- W1966080396 doi "https://doi.org/10.1016/0024-3205(79)90052-3" @default.
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