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- W1966082275 abstract "A pyridoxine (vitamin B6)-deficient diet in rats was used as a model of early renal lithiasis to find out if “stone-formers” could be identified from control animals by differences in the biodistribution of Tc-99m MDP. The mean renal uptake of this agent at 3 hours was about 70% higher in test animals than in controls, but there was considerable overlap between the upper limits of the normal range and lower values in “stone-formers.” If these results were valid for humans, the metabolic abnormality in males with early stone-forming disease could not be identified with certainty by in vivo measurements of Tc-99m MDP renal uptake alone. However, the skeletal uptake of MDP in the “stone-forming” animals was depressed by 28 to 35%, compared with control rats. Consequently, the renal to skeletal MDP concentration ratio was invariably elevated in “stone-formers” beyond the 95 percentile normal range. Unexpectedly, 76% of the pyridoxine-deficient animals had a higher accumulation of MDP in the myocardium than the upper limit of the normal range. The pyridoxine-deficient diet induced no remarkable early changes in the biodistribution or renal clearance of I-131 Hippuran." @default.
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- W1966082275 date "1984-11-01" @default.
- W1966082275 modified "2023-09-26" @default.
- W1966082275 title "Changes in Renal Uptake of Tc-99m Methylene Diphosphonate (MDP) in Stone-Forming Rats" @default.
- W1966082275 doi "https://doi.org/10.1097/00004424-198411000-00013" @default.
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