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- W1966083344 abstract "Background The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia. Methods Line-scan diffusion tensor imaging (DTI) was used to evaluate diffusion in the fornix in 24 male patients with chronic schizophrenia and 31 male control subjects. Maps of fractional anisotropy (FA) and mean diffusivity (Dm), which are indices sensitive to white-matter integrity, were generated to quantify diffusion within the fornix. We used high spatial resolution magnetic resonance imaging (MRI) to measure hippocampal volume. Results FA and cross-sectional area of the fornix were significantly reduced in patients compared with control subjects. Dm was significantly increased, whereas hippocampal volume was bilaterally reduced in patients. Reduced hippocampal volume was correlated with increased mean Dm and reduced cross-sectional area of the fornix for patients. Patients also showed a significant correlation between reduced scores on neuropsychologic measures of declarative-episodic memory and reduced hippocampal volumes. Conclusions These findings demonstrate a disruption in fornix integrity in patients with schizophrenia. The hippocampus has been shown to be abnormal in schizophrenia. The fornix is one of the main fiber tracts connecting the hippocampus with other brain regions. Few studies have evaluated the fornix in schizophrenia, however. A focus on fornix abnormalities and their association with hippocampal abnormalities might figure importantly in our understanding of the pathophysiology of schizophrenia. Line-scan diffusion tensor imaging (DTI) was used to evaluate diffusion in the fornix in 24 male patients with chronic schizophrenia and 31 male control subjects. Maps of fractional anisotropy (FA) and mean diffusivity (Dm), which are indices sensitive to white-matter integrity, were generated to quantify diffusion within the fornix. We used high spatial resolution magnetic resonance imaging (MRI) to measure hippocampal volume. FA and cross-sectional area of the fornix were significantly reduced in patients compared with control subjects. Dm was significantly increased, whereas hippocampal volume was bilaterally reduced in patients. Reduced hippocampal volume was correlated with increased mean Dm and reduced cross-sectional area of the fornix for patients. Patients also showed a significant correlation between reduced scores on neuropsychologic measures of declarative-episodic memory and reduced hippocampal volumes. These findings demonstrate a disruption in fornix integrity in patients with schizophrenia." @default.
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- W1966083344 date "2006-07-01" @default.
- W1966083344 modified "2023-10-16" @default.
- W1966083344 title "Fornix Integrity and Hippocampal Volume in Male Schizophrenic Patients" @default.
- W1966083344 cites W1485480795 @default.
- W1966083344 cites W1558854723 @default.
- W1966083344 cites W1766313263 @default.
- W1966083344 cites W1874130433 @default.
- W1966083344 cites W1966686596 @default.
- W1966083344 cites W1975292680 @default.
- W1966083344 cites W1977421564 @default.
- W1966083344 cites W1978949387 @default.
- W1966083344 cites W1981340850 @default.
- W1966083344 cites W1983112713 @default.
- W1966083344 cites W1985994929 @default.
- W1966083344 cites W1987498894 @default.
- W1966083344 cites W1990186908 @default.
- W1966083344 cites W1993646796 @default.
- W1966083344 cites W1996104170 @default.
- W1966083344 cites W2000628954 @default.
- W1966083344 cites W2002317701 @default.
- W1966083344 cites W2004425853 @default.
- W1966083344 cites W2004582236 @default.
- W1966083344 cites W2016845091 @default.
- W1966083344 cites W2020652796 @default.
- W1966083344 cites W2026812901 @default.
- W1966083344 cites W2027328104 @default.
- W1966083344 cites W2037588444 @default.
- W1966083344 cites W2041706711 @default.
- W1966083344 cites W2048920034 @default.
- W1966083344 cites W2049723926 @default.
- W1966083344 cites W2050468619 @default.
- W1966083344 cites W2060467098 @default.
- W1966083344 cites W2063001897 @default.
- W1966083344 cites W2073845233 @default.
- W1966083344 cites W2074285696 @default.
- W1966083344 cites W2079937681 @default.
- W1966083344 cites W2088060544 @default.
- W1966083344 cites W2090100673 @default.
- W1966083344 cites W2092562674 @default.
- W1966083344 cites W2095750371 @default.
- W1966083344 cites W2100172760 @default.
- W1966083344 cites W2100346695 @default.
- W1966083344 cites W2100949013 @default.
- W1966083344 cites W2104598584 @default.
- W1966083344 cites W2110496616 @default.
- W1966083344 cites W2116087808 @default.
- W1966083344 cites W2122025249 @default.
- W1966083344 cites W2126217264 @default.
- W1966083344 cites W2136022845 @default.
- W1966083344 cites W2138821679 @default.
- W1966083344 cites W2139739917 @default.
- W1966083344 cites W2144099032 @default.
- W1966083344 cites W2145240519 @default.
- W1966083344 cites W2147971750 @default.
- W1966083344 cites W2150299732 @default.
- W1966083344 cites W2158341864 @default.
- W1966083344 cites W2158715164 @default.
- W1966083344 cites W2161875482 @default.
- W1966083344 cites W2163666228 @default.
- W1966083344 cites W2170032997 @default.
- W1966083344 cites W2415636866 @default.
- W1966083344 cites W4244926575 @default.
- W1966083344 cites W4250653224 @default.
- W1966083344 doi "https://doi.org/10.1016/j.biopsych.2005.09.021" @default.
- W1966083344 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2768597" @default.
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