Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966086401> ?p ?o ?g. }
- W1966086401 endingPage "3772" @default.
- W1966086401 startingPage "3763" @default.
- W1966086401 abstract "Abstract Plasminogen (Plg) facilitates inflammatory cell recruitment, a function that depends upon its binding to Plg receptors (Plg-Rs). However, the Plg-Rs that are critical for cell migration are not well defined. Three previously characterized Plg-Rs (α-enolase, annexin 2, and p11) and a recently identified Plg-R (histone H2B [H2B]) were assessed for their contribution to Plg binding and function on macrophages. Two murine macrophage cell lines (RAW 264.7 and J774A.1) and mouse peritoneal macrophages induced by thioglycollate were analyzed. All 4 Plg-Rs were present on the surface of these cells and showed enhanced expression on the thioglycollate-induced macrophages compared with peripheral blood monocytes. Using blocking Fab fragments to each Plg-R, H2B supported approximately 50% of the Plg binding capacity, whereas the other Plg-Rs contributed less than 25%. Anti-H2B Fab also demonstrated a major role of this Plg-R in plasmin generation and matrix invasion. When mice were treated intravenously with anti-H2B Fab, peritoneal macrophage recruitment in response to thioglycollate was reduced by approximately 45% at 24, 48, and 72 hours, with no effect on blood monocyte levels. Taken together, these data suggest that multiple Plg-Rs do contribute to Plg binding to macrophages, and among these, H2B plays a very prominent and functionally important role." @default.
- W1966086401 created "2016-06-24" @default.
- W1966086401 creator A5042974889 @default.
- W1966086401 creator A5051186225 @default.
- W1966086401 creator A5078745290 @default.
- W1966086401 date "2007-11-15" @default.
- W1966086401 modified "2023-10-10" @default.
- W1966086401 title "Histone H2B as a functionally important plasminogen receptor on macrophages" @default.
- W1966086401 cites W1554351458 @default.
- W1966086401 cites W1586576093 @default.
- W1966086401 cites W1604744894 @default.
- W1966086401 cites W1605718906 @default.
- W1966086401 cites W1608138774 @default.
- W1966086401 cites W1956258286 @default.
- W1966086401 cites W1963562384 @default.
- W1966086401 cites W1963841183 @default.
- W1966086401 cites W1965833739 @default.
- W1966086401 cites W1969448733 @default.
- W1966086401 cites W1971424562 @default.
- W1966086401 cites W1982805789 @default.
- W1966086401 cites W1984995468 @default.
- W1966086401 cites W1991389412 @default.
- W1966086401 cites W1997967362 @default.
- W1966086401 cites W2005134321 @default.
- W1966086401 cites W2009484071 @default.
- W1966086401 cites W2010941357 @default.
- W1966086401 cites W2011742334 @default.
- W1966086401 cites W2015141911 @default.
- W1966086401 cites W2025777610 @default.
- W1966086401 cites W2033472578 @default.
- W1966086401 cites W2034866124 @default.
- W1966086401 cites W2035591620 @default.
- W1966086401 cites W2036925454 @default.
- W1966086401 cites W2037452494 @default.
- W1966086401 cites W2040992661 @default.
- W1966086401 cites W2041157072 @default.
- W1966086401 cites W2042314261 @default.
- W1966086401 cites W2043207076 @default.
- W1966086401 cites W2046600341 @default.
- W1966086401 cites W2046633166 @default.
- W1966086401 cites W2047615912 @default.
- W1966086401 cites W2049999422 @default.
- W1966086401 cites W2073766851 @default.
- W1966086401 cites W2078224514 @default.
- W1966086401 cites W2089840669 @default.
- W1966086401 cites W2094941678 @default.
- W1966086401 cites W2121141343 @default.
- W1966086401 cites W2121300516 @default.
- W1966086401 cites W2122561878 @default.
- W1966086401 cites W2127178118 @default.
- W1966086401 cites W2128649422 @default.
- W1966086401 cites W2132502928 @default.
- W1966086401 cites W2157025000 @default.
- W1966086401 cites W2229049611 @default.
- W1966086401 cites W2291438417 @default.
- W1966086401 cites W2303679498 @default.
- W1966086401 cites W2311972351 @default.
- W1966086401 cites W2414047196 @default.
- W1966086401 cites W2414435255 @default.
- W1966086401 cites W2415350691 @default.
- W1966086401 cites W4232196892 @default.
- W1966086401 cites W51183767 @default.
- W1966086401 doi "https://doi.org/10.1182/blood-2007-03-079392" @default.
- W1966086401 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2077321" @default.
- W1966086401 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/17690254" @default.
- W1966086401 hasPublicationYear "2007" @default.
- W1966086401 type Work @default.
- W1966086401 sameAs 1966086401 @default.
- W1966086401 citedByCount "114" @default.
- W1966086401 countsByYear W19660864012012 @default.
- W1966086401 countsByYear W19660864012013 @default.
- W1966086401 countsByYear W19660864012014 @default.
- W1966086401 countsByYear W19660864012015 @default.
- W1966086401 countsByYear W19660864012016 @default.
- W1966086401 countsByYear W19660864012017 @default.
- W1966086401 countsByYear W19660864012018 @default.
- W1966086401 countsByYear W19660864012019 @default.
- W1966086401 countsByYear W19660864012020 @default.
- W1966086401 countsByYear W19660864012021 @default.
- W1966086401 countsByYear W19660864012022 @default.
- W1966086401 countsByYear W19660864012023 @default.
- W1966086401 crossrefType "journal-article" @default.
- W1966086401 hasAuthorship W1966086401A5042974889 @default.
- W1966086401 hasAuthorship W1966086401A5051186225 @default.
- W1966086401 hasAuthorship W1966086401A5078745290 @default.
- W1966086401 hasBestOaLocation W19660864011 @default.
- W1966086401 hasConcept C153911025 @default.
- W1966086401 hasConcept C170493617 @default.
- W1966086401 hasConcept C181199279 @default.
- W1966086401 hasConcept C185592680 @default.
- W1966086401 hasConcept C202751555 @default.
- W1966086401 hasConcept C203014093 @default.
- W1966086401 hasConcept C2779244956 @default.
- W1966086401 hasConcept C2781071845 @default.
- W1966086401 hasConcept C2781184567 @default.
- W1966086401 hasConcept C553184892 @default.
- W1966086401 hasConcept C55493867 @default.
- W1966086401 hasConcept C86803240 @default.