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- W1966095462 abstract "N APRIL 2000, THE FOOD AND DRUG ADMINISTRATION approved photodynamic therapy with verteporfin (Visudyne) for the treatment of predominantly classic choroidal neovascularization associated with age-related macular degeneration (AMD). Soon afterward, Visudyne became the first line of treatment for eligible cases of neovascular AMD. However, with time, the benefits of this treatment have been disappointing, leading to renewed interest in alternative, potentially more efficacious therapies. Photodynamic therapy is a concept that was first discussed in the early 1900s. Although originally conceived as an oncology treatment to occlude tumor vasculature, photodynamic therapy appeared applicable to ophthalmology, owing to the accessibility of the retina to directed light exposure. In this treatment, a photosensitizer with a specific absorbance profile is administered, followed by exposure of the photosensitizer to an appropriate wavelength of light that elevates the photosensitizer to a higher energy state creating a cascade of photochemical events. For choroidal neovascularization, verteporfin (6 mg/m) is infused intravenously over a 10-minute period, and 5 minutes later, the lesion is exposed to a 689 nm light dose of 50 J/cm for 83 seconds. With this protocol, the laser excites the photosensitizer, which then is thought to generate singlet oxygen and reactive oxygen intermediates that damage cellular structures. Specifically, preclinical studies in experimental animals demonstrated that verteporfin selectively occluded experimentally induced choroidal neovascularization with minimal associated effects to surrounding normal tissues." @default.
- W1966095462 created "2016-06-24" @default.
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- W1966095462 date "2004-03-01" @default.
- W1966095462 modified "2023-10-16" @default.
- W1966095462 title "Photodynamic therapy for age-related macular degeneration: a candid appraisal" @default.
- W1966095462 cites W945208301 @default.
- W1966095462 doi "https://doi.org/10.1016/j.ajo.2003.11.023" @default.
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