FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966097130> ?p ?o ?g. }

• W1966097130 endingPage "317" @default.
• W1966097130 startingPage "309" @default.
• W1966097130 abstract "The clinical course of Crohn's disease after the induction of remission with medical therapy is characterized by unpredictable relapse.To evaluate three surrogate markers, intestinal permeability, mucosal TNFalpha and nuclear factor (NF)-kappaB/IkappaBalpha expression, in order to determine the relationship of these parameters to clinical relapse.Thirty patients with active Crohn's disease were treated with a 10 week course of prednisone using a tapering dosing regimen. Intestinal permeability (lactulose/mannitol [L/M ratio]) was determined at baseline and at the end of prednisone tapering. TNFalpha production and the levels of expression of NF-kappaB/IkappaBalpha were measured in colonic mucosal biopsies obtained after the induction of remission.Twenty-two patients (73%) achieved remission and 50% of patients experienced a clinical relapse during the ensuing 12 months. Treatment with prednisone resulted in a significant decrease in the L/M ratio. Of the patients that relapsed, 75% had a raised L/M ratio at the time of remission compared with 20% of patients with a normal L/M ratio (P < 0.008; hazard ratio = 6.094; CI 1.55, 17.43). Mucosal TNFalpha production was greater in relapsers compared with those who remained in remission. The levels of NF-kappaB in relapsers were significantly greater and levels of cytosolic IkappaBalpha were significantly lower compared with those measured in patients who remained in remission.These findings underscore the importance of incorporating biological parameters of inflammation in determining the clinical course of Crohn's disease." @default.
• W1966097130 created "2016-06-24" @default.
• W1966097130 creator A5018579767 @default.
• W1966097130 creator A5031188113 @default.
• W1966097130 creator A5072304962 @default.
• W1966097130 creator A5091426237 @default.
• W1966097130 date "2003-08-01" @default.
• W1966097130 modified "2023-10-15" @default.
• W1966097130 title "The mechanisms of prednisone inhibition of inflammation in Crohn's disease involve changes in intestinal permeability, mucosal TNFα production and nuclear factor kappa B expression" @default.
• W1966097130 cites W1522773084 @default.
• W1966097130 cites W1573810982 @default.
• W1966097130 cites W1625506357 @default.
• W1966097130 cites W1717444875 @default.
• W1966097130 cites W1745264954 @default.
• W1966097130 cites W1761355724 @default.
• W1966097130 cites W1897551156 @default.
• W1966097130 cites W1967435782 @default.
• W1966097130 cites W1977367746 @default.
• W1966097130 cites W1981588877 @default.
• W1966097130 cites W1986242902 @default.
• W1966097130 cites W1987064800 @default.
• W1966097130 cites W1992851871 @default.
• W1966097130 cites W1995540676 @default.
• W1966097130 cites W1999855196 @default.
• W1966097130 cites W2004839931 @default.
• W1966097130 cites W2017870848 @default.
• W1966097130 cites W2022975557 @default.
• W1966097130 cites W2026222818 @default.
• W1966097130 cites W2030538375 @default.
• W1966097130 cites W2036540989 @default.
• W1966097130 cites W2047398409 @default.
• W1966097130 cites W2061679773 @default.
• W1966097130 cites W2061761418 @default.
• W1966097130 cites W2080195364 @default.
• W1966097130 cites W2087090420 @default.
• W1966097130 cites W2098638622 @default.
• W1966097130 cites W2117192674 @default.
• W1966097130 cites W2122247171 @default.
• W1966097130 cites W2123170641 @default.
• W1966097130 cites W2127460630 @default.
• W1966097130 cites W2135891455 @default.
• W1966097130 cites W2137629644 @default.
• W1966097130 cites W2139481814 @default.
• W1966097130 cites W2149085554 @default.
• W1966097130 cites W2151289937 @default.
• W1966097130 cites W2153551222 @default.
• W1966097130 cites W2153608030 @default.
• W1966097130 cites W2155438550 @default.
• W1966097130 cites W2159414724 @default.
• W1966097130 cites W2165655699 @default.
• W1966097130 cites W2166732143 @default.
• W1966097130 cites W2167539577 @default.
• W1966097130 cites W2168447258 @default.
• W1966097130 cites W2169074329 @default.
• W1966097130 cites W2321453230 @default.
• W1966097130 cites W3149527659 @default.
• W1966097130 cites W4293241248 @default.
• W1966097130 doi "https://doi.org/10.1046/j.1365-2036.2003.01611.x" @default.
• W1966097130 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12895215" @default.
• W1966097130 hasPublicationYear "2003" @default.
• W1966097130 type Work @default.
• W1966097130 sameAs 1966097130 @default.
• W1966097130 citedByCount "48" @default.
• W1966097130 countsByYear W19660971302012 @default.
• W1966097130 countsByYear W19660971302013 @default.
• W1966097130 countsByYear W19660971302014 @default.
• W1966097130 countsByYear W19660971302015 @default.
• W1966097130 countsByYear W19660971302016 @default.
• W1966097130 countsByYear W19660971302017 @default.
• W1966097130 countsByYear W19660971302018 @default.
• W1966097130 countsByYear W19660971302019 @default.
• W1966097130 countsByYear W19660971302020 @default.
• W1966097130 countsByYear W19660971302021 @default.
• W1966097130 countsByYear W19660971302022 @default.
• W1966097130 countsByYear W19660971302023 @default.
• W1966097130 crossrefType "journal-article" @default.
• W1966097130 hasAuthorship W1966097130A5018579767 @default.
• W1966097130 hasAuthorship W1966097130A5031188113 @default.
• W1966097130 hasAuthorship W1966097130A5072304962 @default.
• W1966097130 hasAuthorship W1966097130A5091426237 @default.
• W1966097130 hasBestOaLocation W19660971301 @default.
• W1966097130 hasConcept C126322002 @default.
• W1966097130 hasConcept C17991360 @default.
• W1966097130 hasConcept C203014093 @default.
• W1966097130 hasConcept C2778260677 @default.
• W1966097130 hasConcept C2778720950 @default.
• W1966097130 hasConcept C2779134260 @default.
• W1966097130 hasConcept C2779280984 @default.
• W1966097130 hasConcept C2781071285 @default.
• W1966097130 hasConcept C71924100 @default.
• W1966097130 hasConcept C90924648 @default.
• W1966097130 hasConceptScore W1966097130C126322002 @default.
• W1966097130 hasConceptScore W1966097130C17991360 @default.
• W1966097130 hasConceptScore W1966097130C203014093 @default.
• W1966097130 hasConceptScore W1966097130C2778260677 @default.
• W1966097130 hasConceptScore W1966097130C2778720950 @default.
• W1966097130 hasConceptScore W1966097130C2779134260 @default.
• W1966097130 hasConceptScore W1966097130C2779280984 @default.

• next