FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966100488> ?p ?o ?g. }

• W1966100488 endingPage "341" @default.
• W1966100488 startingPage "334" @default.
• W1966100488 abstract "Depolarization-induced vesicle exocytosis is a complex mechanism involving a number of proteins. In this process, synaptotagmins work as members of the Ca2+-sensing system that triggers the fusion of the synaptic vesicle with the plasma membrane. Synaptotagmin IV (SytIV), an immediate-early gene induced by depolarization in PC12 pheochromocytoma cells and in the hippocampus, has been suggested to work as a negative regulator of neurotransmitter release. Unlike other synaptotagmins, SytIV has an evolutionarily conserved substitution of an aspartate to a serine in the Ca2+ coordination site of its C2A domain, preventing SytIV from binding anionic lipids in a Ca2+-dependent fashion. We used the secretion of human growth hormone (hGH) as a reporter system with which to examine the effects of overexpressing SytIV and other depolarization-induced immediate-early genes (the protein kinases KID-1, SIK, and PIM-1 and the transcription factors rTLE3 and Nurr1) on depolarization-induced vesicle exocytosis in PC12 cells. SytIV overexpression resulted in decreased depolarization-induced hGH release. However, conversion of the unique serine in SytIV to an aspartate eliminated this inhibitory activity. In addition, rTLE3 overexpression produced only a modest increase in spontaneous vesicle exocytosis, whereas KID-1, SIK, PIM-1, and Nurr1 overexpression had no effect on depolarization-induced exocytosis. © 2004 Wiley-Liss, Inc." @default.
• W1966100488 created "2016-06-24" @default.
• W1966100488 creator A5001303264 @default.
• W1966100488 creator A5039110124 @default.
• W1966100488 creator A5054674248 @default.
• W1966100488 creator A5071037763 @default.
• W1966100488 date "2004-01-01" @default.
• W1966100488 modified "2023-09-30" @default.
• W1966100488 title "Synaptotagmin IV overexpression inhibits depolarization-induced exocytosis in PC12 cells" @default.
• W1966100488 cites W1482432683 @default.
• W1966100488 cites W1485367438 @default.
• W1966100488 cites W1515271603 @default.
• W1966100488 cites W1553759318 @default.
• W1966100488 cites W1591133722 @default.
• W1966100488 cites W1644847400 @default.
• W1966100488 cites W1867638637 @default.
• W1966100488 cites W1880170891 @default.
• W1966100488 cites W1968566449 @default.
• W1966100488 cites W1970930136 @default.
• W1966100488 cites W1984724306 @default.
• W1966100488 cites W1984728203 @default.
• W1966100488 cites W1990911867 @default.
• W1966100488 cites W1991748157 @default.
• W1966100488 cites W1996166576 @default.
• W1966100488 cites W1999700412 @default.
• W1966100488 cites W2004806440 @default.
• W1966100488 cites W2008163056 @default.
• W1966100488 cites W2018757497 @default.
• W1966100488 cites W2029160544 @default.
• W1966100488 cites W2032380805 @default.
• W1966100488 cites W2035070093 @default.
• W1966100488 cites W2044679183 @default.
• W1966100488 cites W2045651022 @default.
• W1966100488 cites W2046872857 @default.
• W1966100488 cites W2066856722 @default.
• W1966100488 cites W2087911331 @default.
• W1966100488 cites W2089511766 @default.
• W1966100488 cites W2115249441 @default.
• W1966100488 cites W2136422440 @default.
• W1966100488 cites W2154472809 @default.
• W1966100488 doi "https://doi.org/10.1002/jnr.20072" @default.
• W1966100488 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/15079862" @default.
• W1966100488 hasPublicationYear "2004" @default.
• W1966100488 type Work @default.
• W1966100488 sameAs 1966100488 @default.
• W1966100488 citedByCount "30" @default.
• W1966100488 countsByYear W19661004882012 @default.
• W1966100488 countsByYear W19661004882013 @default.
• W1966100488 countsByYear W19661004882016 @default.
• W1966100488 countsByYear W19661004882017 @default.
• W1966100488 countsByYear W19661004882018 @default.
• W1966100488 countsByYear W19661004882020 @default.
• W1966100488 crossrefType "journal-article" @default.
• W1966100488 hasAuthorship W1966100488A5001303264 @default.
• W1966100488 hasAuthorship W1966100488A5039110124 @default.
• W1966100488 hasAuthorship W1966100488A5054674248 @default.
• W1966100488 hasAuthorship W1966100488A5071037763 @default.
• W1966100488 hasConcept C12554922 @default.
• W1966100488 hasConcept C130316041 @default.
• W1966100488 hasConcept C148785051 @default.
• W1966100488 hasConcept C165254790 @default.
• W1966100488 hasConcept C175969161 @default.
• W1966100488 hasConcept C185592680 @default.
• W1966100488 hasConcept C196330066 @default.
• W1966100488 hasConcept C2909863526 @default.
• W1966100488 hasConcept C4141045 @default.
• W1966100488 hasConcept C41625074 @default.
• W1966100488 hasConcept C49039625 @default.
• W1966100488 hasConcept C55493867 @default.
• W1966100488 hasConcept C65972015 @default.
• W1966100488 hasConcept C86473631 @default.
• W1966100488 hasConcept C86803240 @default.
• W1966100488 hasConcept C95444343 @default.
• W1966100488 hasConceptScore W1966100488C12554922 @default.
• W1966100488 hasConceptScore W1966100488C130316041 @default.
• W1966100488 hasConceptScore W1966100488C148785051 @default.
• W1966100488 hasConceptScore W1966100488C165254790 @default.
• W1966100488 hasConceptScore W1966100488C175969161 @default.
• W1966100488 hasConceptScore W1966100488C185592680 @default.
• W1966100488 hasConceptScore W1966100488C196330066 @default.
• W1966100488 hasConceptScore W1966100488C2909863526 @default.
• W1966100488 hasConceptScore W1966100488C4141045 @default.
• W1966100488 hasConceptScore W1966100488C41625074 @default.
• W1966100488 hasConceptScore W1966100488C49039625 @default.
• W1966100488 hasConceptScore W1966100488C55493867 @default.
• W1966100488 hasConceptScore W1966100488C65972015 @default.
• W1966100488 hasConceptScore W1966100488C86473631 @default.
• W1966100488 hasConceptScore W1966100488C86803240 @default.
• W1966100488 hasConceptScore W1966100488C95444343 @default.
• W1966100488 hasIssue "3" @default.
• W1966100488 hasLocation W19661004881 @default.
• W1966100488 hasLocation W19661004882 @default.
• W1966100488 hasOpenAccess W1966100488 @default.
• W1966100488 hasPrimaryLocation W19661004881 @default.
• W1966100488 hasRelatedWork W1506047834 @default.
• W1966100488 hasRelatedWork W1966100488 @default.
• W1966100488 hasRelatedWork W2088499587 @default.
• W1966100488 hasRelatedWork W2088801302 @default.

• next