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• W1966101329 abstract "Abstract Purpose: The aim of this study was to characterize the primary gp100209-2M-specific T-cell response in vaccine-draining, metastases-free lymph nodes and peripheral blood of peptide-vaccinated stage I to III melanoma patients. Experimental Design: After two or three gp100209-2M vaccinations, sentinel lymph nodes that drained both the primary tumor and adjacent vaccine sites were excised concomitant with wide excision of the tumor. Comparative 7-color flow cytometry phenotype analysis was done on gp100 tetramer-positive CD8+ T cells from sentinel lymph nodes, closely proximate time-related peripheral blood mononuclear cells (PBMC) collected 2 to 4 weeks after sentinel lymph node excision, and on PBMC collected 6 months later after 7 or 11 more immunizations. Lymph node and peripheral blood T cells were tested for proliferative response, functional avidity, and tumor cell–induced CD107 mobilization. Results: The frequencies of gp100-specific CD8+ T cells from time-related PBMC and sentinel lymph nodes were comparable and were similar to those reported for virus-specific memory T cells. Their respective in vitro proliferation responses were also equivalent but statistically higher than proliferation responses of peripheral blood T cells collected after completion of the entire vaccine regimen. By contrast, functional avidity and CD107 responses were significantly higher in circulating T cells. Sentinel lymph node–derived, gp100-specific CD8+ T cells predominantly expressed central and effector memory phenotype signatures, whereas there were higher frequencies of effector T cells in the peripheral blood. Conclusion: Priming immunization with gp100209-2M without coadministration of CD4+ helper T cell–restricted antigens induced the effective expansion of peptide-specific central and effector memory CD8+ T cells with high proliferation potential in vaccine-draining lymph nodes of stage I to III melanoma patients. Lymph node memory T cells gave rise to circulating gp100-specific effector T cells exhibiting increased functional maturation." @default.
• W1966101329 created "2016-06-24" @default.
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• W1966101329 date "2009-04-01" @default.
• W1966101329 modified "2023-10-15" @default.
• W1966101329 title "Characterization of the Class I-Restricted gp100 Melanoma Peptide-stimulated Primary Immune Response in Tumor-Free Vaccine-draining Lymph Nodes and Peripheral Blood" @default.
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• W1966101329 doi "https://doi.org/10.1158/1078-0432.ccr-08-2806" @default.
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