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• W1966102364 abstract "Genome-encoded microRNAs (miRNAs) provide a posttranscriptional regulatory layer, which is important for pancreas development. Differentiation of endocrine cells is controlled by a network of pancreatic transcription factors including Ngn3 and NeuroD/Beta2. However, how specific miRNAs are intertwined into this transcriptional network is not well understood. Here, we characterize the regulation of microRNA-7 (miR-7) by endocrine-specific transcription factors. Our data reveal that three independent miR-7 genes are coexpressed in the pancreas. We have identified conserved blocks upstream of pre-miR-7a-2 and pre-miR-7b and demonstrated by functional assays that they possess promoter activity, which is increased by the expression of NeuroD/Beta2. These data suggest that the endocrine specificity of miR-7 expression is governed by transcriptional mechanisms and involves members of the pancreatic endocrine network of transcription factors." @default.
• W1966102364 created "2016-06-24" @default.
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• W1966102364 date "2012-01-01" @default.
• W1966102364 modified "2023-10-06" @default.
• W1966102364 title "Regulation of Pancreatic microRNA-7 Expression" @default.
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• W1966102364 doi "https://doi.org/10.1155/2012/695214" @default.
• W1966102364 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3362837" @default.
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