FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966103152> ?p ?o ?g. }

• W1966103152 endingPage "18" @default.
• W1966103152 startingPage "10" @default.
• W1966103152 abstract "We have previously demonstrated that Krüppel-like factor 8 (KLF8) participates in oncogenic transformation of mouse fibroblasts and is highly overexpressed in human ovarian cancer. In this work, we first correlated KLF8 overexpression with the aggressiveness of ovarian patient tumors and then tested if KLF8 could transform human ovarian epithelial cells. Using the immortalized non-tumorigenic human ovarian surface epithelial cell line T80 and retroviral infection, we generated cell lines that constitutively overexpress KLF8 alone or its combination with the known ovarian oncogenes c-Myc, Stat3c and/or Akt and examined the cell lines for anchorage-independent growth and tumorigenesis. The soft agar clonogenic assay showed that T80/KLF8 cells formed significantly more colonies than the mock cells. Interestingly, the cells expressing both KLF8 and c-Myc formed the largest amounts of colonies, greater than the sum of colonies formed by the cells expressing KLF8 and c-Myc alone. These results suggested that KLF8 might be a weak oncogene that works cooperatively with c-Myc to transform ovarian cells. Surprisingly, overexpression of KLF8 alone was sufficient to induce tumorigenesis in nude mice resulting in short lifespan irrespective of whether the T80/KLF8 cells were injected subcutaneously, intraperitoneally or orthotopically into the ovarian bursa. Histopathological studies confirmed that the T80/KLF8 tumors were characteristic of human serous ovarian carcinomas. Comparative expression profiling and functional studies identified the cell cycle regulators cyclin D1 and USP44 as primary KLF8 targets and effectors for the T80 transformation. Overall, we identified KLF8 overexpression as an important factor in human ovarian carcinoma pathogenesis." @default.
• W1966103152 created "2016-06-24" @default.
• W1966103152 creator A5001165522 @default.
• W1966103152 creator A5019426711 @default.
• W1966103152 creator A5021380919 @default.
• W1966103152 creator A5040976794 @default.
• W1966103152 creator A5042839840 @default.
• W1966103152 creator A5046789366 @default.
• W1966103152 creator A5078134163 @default.
• W1966103152 date "2012-12-10" @default.
• W1966103152 modified "2023-10-14" @default.
• W1966103152 title "Transformation of human ovarian surface epithelial cells by Krüppel-like factor 8" @default.
• W1966103152 cites W1490464860 @default.
• W1966103152 cites W1964137986 @default.
• W1966103152 cites W1971881132 @default.
• W1966103152 cites W1974762105 @default.
• W1966103152 cites W1976027235 @default.
• W1966103152 cites W1979909416 @default.
• W1966103152 cites W1980907165 @default.
• W1966103152 cites W1984542528 @default.
• W1966103152 cites W1992787379 @default.
• W1966103152 cites W1993354346 @default.
• W1966103152 cites W1993649204 @default.
• W1966103152 cites W1998291423 @default.
• W1966103152 cites W2000728270 @default.
• W1966103152 cites W2002716147 @default.
• W1966103152 cites W2004757982 @default.
• W1966103152 cites W2010397777 @default.
• W1966103152 cites W2010850546 @default.
• W1966103152 cites W2012173473 @default.
• W1966103152 cites W2012318525 @default.
• W1966103152 cites W2015632370 @default.
• W1966103152 cites W2019498572 @default.
• W1966103152 cites W2021188131 @default.
• W1966103152 cites W2022532021 @default.
• W1966103152 cites W2023610294 @default.
• W1966103152 cites W2026324708 @default.
• W1966103152 cites W2030610316 @default.
• W1966103152 cites W2033768738 @default.
• W1966103152 cites W2033961200 @default.
• W1966103152 cites W2036018178 @default.
• W1966103152 cites W2041986831 @default.
• W1966103152 cites W2043877371 @default.
• W1966103152 cites W2053857836 @default.
• W1966103152 cites W2055236991 @default.
• W1966103152 cites W2057788484 @default.
• W1966103152 cites W2064165635 @default.
• W1966103152 cites W2068652698 @default.
• W1966103152 cites W2072268161 @default.
• W1966103152 cites W2073343679 @default.
• W1966103152 cites W2073575984 @default.
• W1966103152 cites W2105761963 @default.
• W1966103152 cites W2106969933 @default.
• W1966103152 cites W2109528117 @default.
• W1966103152 cites W2113807582 @default.
• W1966103152 cites W2125536613 @default.
• W1966103152 cites W2135179721 @default.
• W1966103152 cites W2142835688 @default.
• W1966103152 cites W2144720355 @default.
• W1966103152 cites W2158436808 @default.
• W1966103152 doi "https://doi.org/10.1038/onc.2012.545" @default.
• W1966103152 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3975924" @default.
• W1966103152 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23222713" @default.
• W1966103152 hasPublicationYear "2012" @default.
• W1966103152 type Work @default.
• W1966103152 sameAs 1966103152 @default.
• W1966103152 citedByCount "35" @default.
• W1966103152 countsByYear W19661031522013 @default.
• W1966103152 countsByYear W19661031522014 @default.
• W1966103152 countsByYear W19661031522015 @default.
• W1966103152 countsByYear W19661031522016 @default.
• W1966103152 countsByYear W19661031522017 @default.
• W1966103152 countsByYear W19661031522018 @default.
• W1966103152 countsByYear W19661031522019 @default.
• W1966103152 countsByYear W19661031522020 @default.
• W1966103152 countsByYear W19661031522021 @default.
• W1966103152 countsByYear W19661031522022 @default.
• W1966103152 countsByYear W19661031522023 @default.
• W1966103152 crossrefType "journal-article" @default.
• W1966103152 hasAuthorship W1966103152A5001165522 @default.
• W1966103152 hasAuthorship W1966103152A5019426711 @default.
• W1966103152 hasAuthorship W1966103152A5021380919 @default.
• W1966103152 hasAuthorship W1966103152A5040976794 @default.
• W1966103152 hasAuthorship W1966103152A5042839840 @default.
• W1966103152 hasAuthorship W1966103152A5046789366 @default.
• W1966103152 hasAuthorship W1966103152A5078134163 @default.
• W1966103152 hasBestOaLocation W19661031521 @default.
• W1966103152 hasConcept C121608353 @default.
• W1966103152 hasConcept C1491633281 @default.
• W1966103152 hasConcept C2780427987 @default.
• W1966103152 hasConcept C2781018059 @default.
• W1966103152 hasConcept C29537977 @default.
• W1966103152 hasConcept C502942594 @default.
• W1966103152 hasConcept C54355233 @default.
• W1966103152 hasConcept C555283112 @default.
• W1966103152 hasConcept C81885089 @default.
• W1966103152 hasConcept C86803240 @default.
• W1966103152 hasConceptScore W1966103152C121608353 @default.

• next