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• W1966103520 abstract "Domains are the main structural and functional units of larger proteins. They tend to be contiguous in primary structure and can fold and function independently. It has been observed that 10–20% of all encoded proteins contain duplicated domains and the average pairwise sequence identity between them is usually low. In the present study, we have analyzed the structural similarity between domain repeats of proteins with known structures available in the Protein Data Bank using structure-based inter-residue interaction measures such as the number of long-range contacts, surrounding hydrophobicity, and pairwise interaction energy. We used RADAR program for detecting the repeats in a protein sequence which were further validated using Pfam domain assignments. The sequence identity between the repeats in domains ranges from 20 to 40% and their secondary structural elements are well conserved. The number of long-range contacts, surrounding hydrophobicity calculations and pairwise interaction energy of the domain repeats clearly reveal the conservation of 3-D structure environment in the repeats of domains. The proportions of mainchain–mainchain hydrogen bonds and hydrophobic interactions are also highly conserved between the repeats. The present study has suggested that the computation of these structure-based parameters will give better clues about the tertiary environment of the repeats in domains. The folding rates of individual domains in the repeats predicted using the long-range order parameter indicate that the predicted folding rates correlate well with most of the experimentally observed folding rates for the analyzed independently folded domains." @default.
• W1966103520 created "2016-06-24" @default.
• W1966103520 creator A5045381149 @default.
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• W1966103520 date "2014-04-07" @default.
• W1966103520 modified "2023-09-23" @default.
• W1966103520 title "Conservation of inter-residue interactions and prediction of folding rates of domain repeats" @default.
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• W1966103520 doi "https://doi.org/10.1080/07391102.2014.894944" @default.
• W1966103520 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24702623" @default.
• W1966103520 hasPublicationYear "2014" @default.
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