Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966109112> ?p ?o ?g. }
- W1966109112 endingPage "122" @default.
- W1966109112 startingPage "112" @default.
- W1966109112 abstract "Cannabinoid CB1 inverse agonists suppress food-motivated behaviors, but may also induce psychiatric effects such as depression and anxiety. To evaluate behaviors potentially related to anxiety, the present experiments assessed the CB1 inverse agonist AM251 (2.0–8.0 mg/kg), the CB1 antagonist AM4113 (3.0–12.0 mg/kg), and the benzodiazepine inverse agonist FG-7142 (10.0–20.0 mg/kg), using the open field test and the elevated plus maze. Although all three drugs affected open field behavior, these effects were largely due to actions on locomotion. In the elevated plus maze, FG-7142 and AM251 both produced anxiogenic effects. FG-7142 and AM251 also significantly increased c-Fos activity in the amygdala and nucleus accumbens shell. In contrast, AM4113 failed to affect performance in the plus maze, and did not induce c-Fos immunoreactivity. The weak effects of AM4113 are consistent with biochemical data showing that AM4113 induces little or no intrinsic cellular activity. This research may lead to the development of novel appetite suppressants with reduced anxiogenic effects." @default.
- W1966109112 created "2016-06-24" @default.
- W1966109112 creator A5000540926 @default.
- W1966109112 creator A5010117184 @default.
- W1966109112 creator A5019481382 @default.
- W1966109112 creator A5029356971 @default.
- W1966109112 creator A5029694891 @default.
- W1966109112 creator A5032964866 @default.
- W1966109112 creator A5042488292 @default.
- W1966109112 creator A5049904983 @default.
- W1966109112 creator A5059365702 @default.
- W1966109112 creator A5091791907 @default.
- W1966109112 date "2010-02-01" @default.
- W1966109112 modified "2023-10-18" @default.
- W1966109112 title "Potential anxiogenic effects of cannabinoid CB1 receptor antagonists/inverse agonists in rats: Comparisons between AM4113, AM251, and the benzodiazepine inverse agonist FG-7142" @default.
- W1966109112 cites W1540034831 @default.
- W1966109112 cites W157867011 @default.
- W1966109112 cites W1964592768 @default.
- W1966109112 cites W1965117109 @default.
- W1966109112 cites W1965981503 @default.
- W1966109112 cites W1966037459 @default.
- W1966109112 cites W1966899919 @default.
- W1966109112 cites W1971698096 @default.
- W1966109112 cites W1975190631 @default.
- W1966109112 cites W1975744829 @default.
- W1966109112 cites W1975748753 @default.
- W1966109112 cites W1977256878 @default.
- W1966109112 cites W1981568616 @default.
- W1966109112 cites W1981786001 @default.
- W1966109112 cites W1982291289 @default.
- W1966109112 cites W1983493680 @default.
- W1966109112 cites W1983721187 @default.
- W1966109112 cites W1990949546 @default.
- W1966109112 cites W1991778481 @default.
- W1966109112 cites W1993764059 @default.
- W1966109112 cites W1995692468 @default.
- W1966109112 cites W1999593888 @default.
- W1966109112 cites W2000202497 @default.
- W1966109112 cites W2005383811 @default.
- W1966109112 cites W2007323738 @default.
- W1966109112 cites W2009732294 @default.
- W1966109112 cites W2016078965 @default.
- W1966109112 cites W2026800992 @default.
- W1966109112 cites W2027352187 @default.
- W1966109112 cites W2027478606 @default.
- W1966109112 cites W2028318252 @default.
- W1966109112 cites W2031023109 @default.
- W1966109112 cites W2031806630 @default.
- W1966109112 cites W2033818328 @default.
- W1966109112 cites W2035743528 @default.
- W1966109112 cites W2036465008 @default.
- W1966109112 cites W2041561931 @default.
- W1966109112 cites W2047029495 @default.
- W1966109112 cites W2048020266 @default.
- W1966109112 cites W2049811207 @default.
- W1966109112 cites W2051180319 @default.
- W1966109112 cites W205408129 @default.
- W1966109112 cites W2054610687 @default.
- W1966109112 cites W2060266020 @default.
- W1966109112 cites W2060528629 @default.
- W1966109112 cites W2060645936 @default.
- W1966109112 cites W2064885604 @default.
- W1966109112 cites W2067421324 @default.
- W1966109112 cites W2071924132 @default.
- W1966109112 cites W2076532454 @default.
- W1966109112 cites W2078348242 @default.
- W1966109112 cites W2079714688 @default.
- W1966109112 cites W2083861794 @default.
- W1966109112 cites W2087052199 @default.
- W1966109112 cites W2087180408 @default.
- W1966109112 cites W2087444912 @default.
- W1966109112 cites W2087587748 @default.
- W1966109112 cites W2090772580 @default.
- W1966109112 cites W2095133395 @default.
- W1966109112 cites W2098553579 @default.
- W1966109112 cites W2115736681 @default.
- W1966109112 cites W2116322199 @default.
- W1966109112 cites W2119458823 @default.
- W1966109112 cites W2124733378 @default.
- W1966109112 cites W2124997151 @default.
- W1966109112 cites W2149156948 @default.
- W1966109112 cites W2165269657 @default.
- W1966109112 cites W2168128112 @default.
- W1966109112 cites W2202871087 @default.
- W1966109112 cites W4241363254 @default.
- W1966109112 doi "https://doi.org/10.1016/j.euroneuro.2009.11.002" @default.
- W1966109112 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/2817975" @default.
- W1966109112 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/20015619" @default.
- W1966109112 hasPublicationYear "2010" @default.
- W1966109112 type Work @default.
- W1966109112 sameAs 1966109112 @default.
- W1966109112 citedByCount "72" @default.
- W1966109112 countsByYear W19661091122012 @default.
- W1966109112 countsByYear W19661091122013 @default.
- W1966109112 countsByYear W19661091122014 @default.
- W1966109112 countsByYear W19661091122015 @default.
- W1966109112 countsByYear W19661091122016 @default.
- W1966109112 countsByYear W19661091122017 @default.