Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966111248> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W1966111248 endingPage "132" @default.
- W1966111248 startingPage "123" @default.
- W1966111248 abstract "dl-α-Hydrazinoimidazolylpropionic acid (dl-HIPA), a potent competitive inhibitor of rat liver histidine ammonia-lyase, was found to produce a partial (more than 70%) inactivation of this enzyme in vivo when administered intraperitoneally to rats. This inactivation was irreversible, as demonstrated by the failure of prolonged dialysis to restore the histidine ammonia-lyase activity of liver extracts from dl-HIPA treated rats and by the extended duration of the depression of enzyme activity following injection of this compound. The inactivation phenomenon was dose-dependent and specific for dlHIPA; administration of other hydrazine compounds to rats was without effect on hepatic histidine ammonia-lyase activity. Although dl-HIPA produced only slight inactivation of partially purified rat liver histidine ammonia-lyase in vitro, this process was greatly enhanced by the combined presence in the incubation medium of liver microsomes, NADPH, and O2. Rats pretreated with phenobarbital were found to be significantly more sensitive to histidine ammonia-lyase inactivation in vivo following dl-HIPA administration than were saline-injected controls. These findings suggest dl-HIPA to inactivate rat liver histidine ammonia-lyase in vivo by a specific, indirect mechanism, possibly involving the prior interaction of this compound with a microsomal mixed-function oxidase." @default.
- W1966111248 created "2016-06-24" @default.
- W1966111248 creator A5026320132 @default.
- W1966111248 creator A5067834457 @default.
- W1966111248 date "1976-11-01" @default.
- W1966111248 modified "2023-10-16" @default.
- W1966111248 title "dl-α-Hydrazinoimidazolylpropionic acid: An irreversible inhibitor of hepatic histidine ammonia-lyase in vivo" @default.
- W1966111248 cites W1483711063 @default.
- W1966111248 cites W1530558050 @default.
- W1966111248 cites W1538363759 @default.
- W1966111248 cites W1546296744 @default.
- W1966111248 cites W1589858311 @default.
- W1966111248 cites W1645423248 @default.
- W1966111248 cites W1775749144 @default.
- W1966111248 cites W1804005750 @default.
- W1966111248 cites W1809209698 @default.
- W1966111248 cites W1957381779 @default.
- W1966111248 cites W1974487154 @default.
- W1966111248 cites W1980353363 @default.
- W1966111248 cites W1984660061 @default.
- W1966111248 cites W1985116796 @default.
- W1966111248 cites W1998374673 @default.
- W1966111248 cites W2006329471 @default.
- W1966111248 cites W2006999137 @default.
- W1966111248 cites W2011381010 @default.
- W1966111248 cites W2034526640 @default.
- W1966111248 cites W2049868455 @default.
- W1966111248 cites W2054504513 @default.
- W1966111248 cites W2072722067 @default.
- W1966111248 cites W2085382015 @default.
- W1966111248 cites W2086528904 @default.
- W1966111248 cites W2087595634 @default.
- W1966111248 cites W2092704281 @default.
- W1966111248 cites W2094910676 @default.
- W1966111248 cites W2318454726 @default.
- W1966111248 cites W2330388229 @default.
- W1966111248 cites W2471425821 @default.
- W1966111248 cites W284452739 @default.
- W1966111248 cites W77531831 @default.
- W1966111248 doi "https://doi.org/10.1016/0003-9861(76)90422-7" @default.
- W1966111248 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/999282" @default.
- W1966111248 hasPublicationYear "1976" @default.
- W1966111248 type Work @default.
- W1966111248 sameAs 1966111248 @default.
- W1966111248 citedByCount "4" @default.
- W1966111248 crossrefType "journal-article" @default.
- W1966111248 hasAuthorship W1966111248A5026320132 @default.
- W1966111248 hasAuthorship W1966111248A5067834457 @default.
- W1966111248 hasConcept C150903083 @default.
- W1966111248 hasConcept C181199279 @default.
- W1966111248 hasConcept C185592680 @default.
- W1966111248 hasConcept C207001950 @default.
- W1966111248 hasConcept C2776382133 @default.
- W1966111248 hasConcept C2777269803 @default.
- W1966111248 hasConcept C2778460671 @default.
- W1966111248 hasConcept C55493867 @default.
- W1966111248 hasConcept C86803240 @default.
- W1966111248 hasConcept C87644729 @default.
- W1966111248 hasConceptScore W1966111248C150903083 @default.
- W1966111248 hasConceptScore W1966111248C181199279 @default.
- W1966111248 hasConceptScore W1966111248C185592680 @default.
- W1966111248 hasConceptScore W1966111248C207001950 @default.
- W1966111248 hasConceptScore W1966111248C2776382133 @default.
- W1966111248 hasConceptScore W1966111248C2777269803 @default.
- W1966111248 hasConceptScore W1966111248C2778460671 @default.
- W1966111248 hasConceptScore W1966111248C55493867 @default.
- W1966111248 hasConceptScore W1966111248C86803240 @default.
- W1966111248 hasConceptScore W1966111248C87644729 @default.
- W1966111248 hasIssue "1" @default.
- W1966111248 hasLocation W19661112481 @default.
- W1966111248 hasLocation W19661112482 @default.
- W1966111248 hasOpenAccess W1966111248 @default.
- W1966111248 hasPrimaryLocation W19661112481 @default.
- W1966111248 hasRelatedWork W1496234280 @default.
- W1966111248 hasRelatedWork W1619794196 @default.
- W1966111248 hasRelatedWork W1987437433 @default.
- W1966111248 hasRelatedWork W2010372900 @default.
- W1966111248 hasRelatedWork W2042153386 @default.
- W1966111248 hasRelatedWork W2046311107 @default.
- W1966111248 hasRelatedWork W2139062079 @default.
- W1966111248 hasRelatedWork W2290318361 @default.
- W1966111248 hasRelatedWork W2326549699 @default.
- W1966111248 hasRelatedWork W2402972911 @default.
- W1966111248 hasVolume "177" @default.
- W1966111248 isParatext "false" @default.
- W1966111248 isRetracted "false" @default.
- W1966111248 magId "1966111248" @default.
- W1966111248 workType "article" @default.