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- W1966114916 abstract "The involvement of K+ channels in the autoregulation of terminal serotonin (5-hydroxytryptamine, 5-HT) release was investigated by microdialysis in the hippocampus of conscious rats. Extracellular 5-HT was increased concentration-dependently by the K+ channel blocker quinine (10, 100 and 1000 μM in perfusate), and tetrodotoxin (10 μM) but not fluoxetine (5 μM) exerted a partially attenuating influence. The 5-HT1/2/6 receptor antagonist methiothepin (50 μM) increased dialysate 5-HT, most likely through 5-HT1B autoreceptors tonically activated in the hippocampus of awake rats as opposed to the previously reported lack of effect 5-HT1B autoreceptor blockade in anesthetized rats. The effect of methiothepin was greatly reduced by preperfusion with quinine (100 μM), consonant with a role for quinine-sensitive K+ channels in the autoregulation of 5-HT release in the hippocampus by 5-HT receptor antagonism. In contrast, the reduction in dialysate 5-HT induced by the 5-HT1 receptor agonist RU 24969 (1 μM), in the presence of fluoxetine (5 μM), persisted in the co-presence of quinine, consonant with the involvement of (extrasynaptic?) 5-HT autoreceptors not coupled with quinine-sensitive K+ channels." @default.
- W1966114916 created "2016-06-24" @default.
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- W1966114916 date "1997-12-01" @default.
- W1966114916 modified "2023-10-18" @default.
- W1966114916 title "Effect of quinine on autoreceptor-regulated serotonin release in the rat hippocampus" @default.
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- W1966114916 doi "https://doi.org/10.1016/s0014-2999(97)01421-0" @default.
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