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- W1966116688 abstract "Abstract The action of individual r II + genes of bacteriophage T4 was analyzed by crosses between ultraviolet-sterilized wild-type phage and unirradiated phage mutant for the gene being investigated. Inactivation of a gene (i.e., loss of its capacity for phenotypic action) was characterized by a single-hit relation to dose, with a sensitivity of 0.10 and 0.05 per phage-lethal damage for the A and B cistrons, respectively. The presence of an r II + gene in the progeny of a cross was also studied. This phenomenon, called cross reactivation (CR), involves genetic duplication and recombination of irradiated phage. In some experiments doubly mutant phage was used for simultaneous analyses of two genes. The interpretation of these experiments is based on the assumption that cistrons (genes, or, more precisely, genetic units of function) occupy certain lengths along the phage linkage structure (“chromosome”). A radiation-induced damage on this chromosome will inactivate a phage, but a phage's undamaged components may act in a mixed infection. A damage located anywhere within a cistron destroys its capacity for phenotypic action. Undamaged specific genetic elements may be rescued by CR. “Survival of phenotype” (SP) is not normally a prerequisite for CR; in these experiments, however, survival of the phenotype of the particular r II + gene being investigated was a necessary (but not sufficient) condition for CR. The experiments are discussed with regard to the role of phage genes in initiating infection and with regard to radiation genetics, with particular attention to cross reactivation and multiplicity reactivation of bacteriophage." @default.
- W1966116688 created "2016-06-24" @default.
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- W1966116688 date "1959-05-01" @default.
- W1966116688 modified "2023-09-23" @default.
- W1966116688 title "A study of gene action in ultraviolet-irradiated bacteriophage T4" @default.
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- W1966116688 doi "https://doi.org/10.1016/0042-6822(59)90021-2" @default.
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