FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W1966118557> ?p ?o ?g. }

• W1966118557 endingPage "1075" @default.
• W1966118557 startingPage "1062" @default.
• W1966118557 abstract "Single-marker linkage-disequilibrium (LD) methods cannot fully describe disequilibrium in an entire chromosomal region surrounding a disease allele. With the advent of myriad tightly linked microsatellite markers, we have an opportunity to extend LD analysis from single markers to multiple-marker haplotypes. Haplotype analysis has increased statistical power to disclose the presence of a disease locus in situations where it correctly reflects the historical process involved. For maximum efficiency, evidence of LD ought to come not just from a single haplotype, which may well be rare, but in addition from many similar haplotypes that could have descended from the same ancestral founder but have been trimmed in succeeding generations. We present such an analysis, called the trimmed-haplotype method. We focus on chromosomal regions that are small enough that disequilibrium in significant portions of them may have been preserved in some pedigrees and yet that contain enough markers to minimize coincidental occurrence of the haplotype in the absence of a disease allele: perhaps regions 1-2 cM in length. In general, we could have no idea what haplotype an ancestral founder carried generations ago, nor do we usually have a precise chromosomal location for the disease-susceptibility locus. Therefore, we must search through all possible haplotypes surrounding multiple locations. Since such repeated testing obliterates the sampling distribution of the test, we employ bootstrap methods to calculate significance levels. Trimmed-haplotype analysis is performed on family data in which genotypes have been assembled into haplotypes. It can be applied either to conventional parent-affected-offspring triads or to multiplex pedigrees. We present a method for summarizing the LD evidence, in any pedigree, that can be employed in trimmed-haplotype analysis as well as in other methods." @default.
• W1966118557 created "2016-06-24" @default.
• W1966118557 creator A5011961838 @default.
• W1966118557 creator A5018516395 @default.
• W1966118557 creator A5036233331 @default.
• W1966118557 creator A5036719024 @default.
• W1966118557 creator A5084372336 @default.
• W1966118557 creator A5084711681 @default.
• W1966118557 date "2000-03-01" @default.
• W1966118557 modified "2023-10-14" @default.
• W1966118557 title "The Trimmed-Haplotype Test for Linkage Disequilibrium" @default.
• W1966118557 cites W1482486479 @default.
• W1966118557 cites W1543868019 @default.
• W1966118557 cites W1590326214 @default.
• W1966118557 cites W1605596740 @default.
• W1966118557 cites W193590840 @default.
• W1966118557 cites W1965871695 @default.
• W1966118557 cites W1968664402 @default.
• W1966118557 cites W1972880351 @default.
• W1966118557 cites W1989432434 @default.
• W1966118557 cites W1996468809 @default.
• W1966118557 cites W2005571101 @default.
• W1966118557 cites W2046505883 @default.
• W1966118557 cites W2049341757 @default.
• W1966118557 cites W2049414355 @default.
• W1966118557 cites W2059543915 @default.
• W1966118557 cites W2071880067 @default.
• W1966118557 cites W2074243824 @default.
• W1966118557 cites W2084506025 @default.
• W1966118557 cites W2112066577 @default.
• W1966118557 cites W2117242410 @default.
• W1966118557 cites W2148755629 @default.
• W1966118557 cites W2150100666 @default.
• W1966118557 cites W2156853294 @default.
• W1966118557 cites W2156989422 @default.
• W1966118557 cites W2163517519 @default.
• W1966118557 doi "https://doi.org/10.1086/302796" @default.
• W1966118557 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/1288142" @default.
• W1966118557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10712218" @default.
• W1966118557 hasPublicationYear "2000" @default.
• W1966118557 type Work @default.
• W1966118557 sameAs 1966118557 @default.
• W1966118557 citedByCount "35" @default.
• W1966118557 countsByYear W19661185572013 @default.
• W1966118557 countsByYear W19661185572014 @default.
• W1966118557 countsByYear W19661185572017 @default.
• W1966118557 crossrefType "journal-article" @default.
• W1966118557 hasAuthorship W1966118557A5011961838 @default.
• W1966118557 hasAuthorship W1966118557A5018516395 @default.
• W1966118557 hasAuthorship W1966118557A5036233331 @default.
• W1966118557 hasAuthorship W1966118557A5036719024 @default.
• W1966118557 hasAuthorship W1966118557A5084372336 @default.
• W1966118557 hasAuthorship W1966118557A5084711681 @default.
• W1966118557 hasBestOaLocation W19661185571 @default.
• W1966118557 hasConcept C104317684 @default.
• W1966118557 hasConcept C118487528 @default.
• W1966118557 hasConcept C180754005 @default.
• W1966118557 hasConcept C197754878 @default.
• W1966118557 hasConcept C22593422 @default.
• W1966118557 hasConcept C2778146401 @default.
• W1966118557 hasConcept C35605836 @default.
• W1966118557 hasConcept C44432683 @default.
• W1966118557 hasConcept C54355233 @default.
• W1966118557 hasConcept C61320498 @default.
• W1966118557 hasConcept C71924100 @default.
• W1966118557 hasConcept C78458016 @default.
• W1966118557 hasConcept C84597430 @default.
• W1966118557 hasConcept C86803240 @default.
• W1966118557 hasConceptScore W1966118557C104317684 @default.
• W1966118557 hasConceptScore W1966118557C118487528 @default.
• W1966118557 hasConceptScore W1966118557C180754005 @default.
• W1966118557 hasConceptScore W1966118557C197754878 @default.
• W1966118557 hasConceptScore W1966118557C22593422 @default.
• W1966118557 hasConceptScore W1966118557C2778146401 @default.
• W1966118557 hasConceptScore W1966118557C35605836 @default.
• W1966118557 hasConceptScore W1966118557C44432683 @default.
• W1966118557 hasConceptScore W1966118557C54355233 @default.
• W1966118557 hasConceptScore W1966118557C61320498 @default.
• W1966118557 hasConceptScore W1966118557C71924100 @default.
• W1966118557 hasConceptScore W1966118557C78458016 @default.
• W1966118557 hasConceptScore W1966118557C84597430 @default.
• W1966118557 hasConceptScore W1966118557C86803240 @default.
• W1966118557 hasIssue "3" @default.
• W1966118557 hasLocation W19661185571 @default.
• W1966118557 hasLocation W19661185572 @default.
• W1966118557 hasLocation W19661185573 @default.
• W1966118557 hasLocation W19661185574 @default.
• W1966118557 hasOpenAccess W1966118557 @default.
• W1966118557 hasPrimaryLocation W19661185571 @default.
• W1966118557 hasRelatedWork W1483645542 @default.
• W1966118557 hasRelatedWork W1551477413 @default.
• W1966118557 hasRelatedWork W1985016466 @default.
• W1966118557 hasRelatedWork W2006028276 @default.
• W1966118557 hasRelatedWork W2025865556 @default.
• W1966118557 hasRelatedWork W2028170846 @default.
• W1966118557 hasRelatedWork W2060768610 @default.
• W1966118557 hasRelatedWork W2081569445 @default.
• W1966118557 hasRelatedWork W2156962027 @default.

• next